C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: epoxide hydrolase 2, cytoplasmic
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000120915 EPHX2 9606 + 8:27490779-27545564 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000380476 EPHX2-002 27491166-27544913 protein_coding
  ENST00000517536 EPHX2-003 27491125-27544919 protein_coding
  ENST00000518328 EPHX2-011 27490781-27505084 protein_coding
  ENST00000518379 EPHX2-005 27491192-27544892 protein_coding
  ENST00000520623 EPHX2-009 27491125-27539255 retained_intron
  ENST00000520666 EPHX2-012 27491195-27506904 processed_transcript
  ENST00000521400 EPHX2-001 27490779-27545564 protein_coding
  ENST00000521684 EPHX2-017 27491210-27522509 protein_coding
  ENST00000521780 EPHX2-008 27491151-27544919 protein_coding
  ENST00000521924 EPHX2-016 27505047-27512100 retained_intron
  ENST00000523326 EPHX2-015 27515463-27522487 retained_intron
  ENST00000523827 EPHX2-014 27492842-27503759 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000380476ENST00000517536ENST00000518328ENST00000518379ENST00000520623ENST00000520666ENST00000521400ENST00000521780
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000380476 3.950±0.00 4.163±0.00 6.508±0.00 N/A 6.090±5.17 4.973±1.95 6.166±0.00 18.431±8.71 13.665±12.23 N/A 0.399±0.00 11.279±5.58 2.860±0.13 3.980±0.00
ENST00000517536 N/A 1.608±0.00 N/A 0.916±0.45 3.848±0.00 3.331±0.40 0.396±0.00 17.854±0.00 11.216±0.00 0.962±0.25 0.947±0.00 6.458±1.34 6.359±4.77 6.654±3.77
ENST00000518328 N/A N/A 57.200±0.00 1.450±0.00 6.012±0.00 22.694±0.00 1.253±0.00 109.312±0.00 4.842±0.00 5.189±0.00 0.450±0.00 3.964±0.00 N/A N/A
ENST00000518379 N/A N/A N/A 2.058±0.00 N/A N/A N/A N/A N/A 1.487±0.00 1.013±0.00 2.499±0.00 1.454±0.08 1.707±0.00
ENST00000520623 N/A N/A 4.346±0.00 0.624±0.00 N/A N/A 1.283±0.00 N/A 1.262±0.00 0.584±0.00 N/A N/A N/A N/A
ENST00000520666 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.572±0.00 N/A N/A N/A
ENST00000521400 N/A N/A 4.151±0.00 N/A N/A N/A N/A N/A N/A 0.294±0.00 N/A N/A N/A N/A
ENST00000521780 N/A N/A N/A 0.282±0.00 N/A N/A N/A N/A 8.735±0.00 3.249±0.00 1.314±0.00 5.732±0.00 3.343±0.41 1.561±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0003824 IEA catalytic activity
GO:0004301 IDA epoxide hydrolase activity
GO:0005102 IPI receptor binding
GO:0005777 IDA peroxisome
GO:0005829 NAS cytosol
GO:0006805 NAS xenobiotic metabolic process
GO:0006874 NAS cellular calcium ion homeostasis
GO:0006954 NAS inflammatory response
GO:0008152 IEA metabolic process
GO:0008217 NAS regulation of blood pressure
GO:0009636 NAS response to toxic substance
GO:0010628 IDA positive regulation of gene expression
GO:0015643 IDA toxic substance binding
GO:0016311 IDA dephosphorylation
GO:0016787 IEA hydrolase activity
GO:0016791 IDA phosphatase activity
GO:0017144 NAS drug metabolic process
GO:0019369 TAS arachidonic acid metabolic process
GO:0019373 TAS epoxygenase P450 pathway
GO:0033885 IEA 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
GO:0042577 IDA lipid phosphatase activity
GO:0042632 IDA cholesterol homeostasis
GO:0042803 NAS protein homodimerization activity
GO:0044281 TAS small molecule metabolic process
GO:0045909 NAS positive regulation of vasodilation
GO:0046272 IDA stilbene catabolic process
GO:0046839 IDA phospholipid dephosphorylation
GO:0070062 IDA extracellular vesicular exosome
GO:0072593 NAS reactive oxygen species metabolic process
GO:0090181 IMP regulation of cholesterol metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040255 ephx2 epoxide hydrolase 2, cytoplasmic protein_coding Danio_rerio
ENSMUSG00000022040 Ephx2 epoxide hydrolase 2, cytoplasmic protein_coding Mus_musculus

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