C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fms-related tyrosine kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000122025 FLT3 9606 - 13:28003274-28100592 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000241453 FLT3-001 28003274-28100592 protein_coding
  ENST00000380987 FLT3-002 28003614-28100592 nonsense_mediated_decay
  ENST00000469894 FLT3-003 28003947-28014512 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000241453ENST00000380987ENST00000469894
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000241453 0.073±0.00 0.453±0.00 0.250±0.00 N/A N/A 0.016±0.00 0.022±0.00 N/A 0.105±0.00 0.083±0.04 0.028±0.00 0.241±0.04
ENST00000380987 N/A N/A 0.229±0.00 0.035±0.00 0.054±0.04 0.089±0.00 0.409±0.00 0.123±0.04 0.583±0.00 0.070±0.01 0.050±0.01 0.062±0.00
ENST00000469894 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.082±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008CO CIL_0008CO_0001 VISTA 13:27444442-28045997
CIL_0007MT CIL_0007MT_0001 UCNEbase 13:27505095-28294517
CIL_00082E CIL_00082E_0001 VISTA 13:27521824-28123399
CIL_0000G8 CIL_0000G8_0002 CGP 13:27977714-28100592
CIL_0000G0 CIL_0000G0_0002 CGP 13:28003274-28295335

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001776 ISS leukocyte homeostasis
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002318 ISS myeloid progenitor cell differentiation
GO:0002320 IEA lymphoid progenitor cell differentiation
GO:0002328 ISS pro-B cell differentiation
GO:0002572 IEA pro-T cell differentiation
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 TAS:IEA transmembrane receptor protein tyrosine kinase activity
GO:0004896 ISS cytokine receptor activity
GO:0005021 TAS vascular endothelial growth factor-activated receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005783 IEA endoplasmic reticulum
GO:0005829 IEA cytosol
GO:0005886 IEA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007169 TAS:IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284 TAS positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0009897 IEA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0010243 IEA response to organonitrogen compound
GO:0014068 TAS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 TAS peptidyl-tyrosine phosphorylation
GO:0019221 ISS cytokine-mediated signaling pathway
GO:0030097 IDA hemopoiesis
GO:0030098 IEA lymphocyte differentiation
GO:0030183 ISS B cell differentiation
GO:0031100 IEA organ regeneration
GO:0032403 IEA protein complex binding
GO:0035259 IEA glucocorticoid receptor binding
GO:0035726 ISS common myeloid progenitor cell proliferation
GO:0038084 TAS vascular endothelial growth factor signaling pathway
GO:0042531 TAS positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 TAS protein homodimerization activity
GO:0042981 TAS regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0043406 TAS positive regulation of MAP kinase activity
GO:0043410 TAS positive regulation of MAPK cascade
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0043552 TAS positive regulation of phosphatidylinositol 3-kinase activity
GO:0045578 IEA negative regulation of B cell differentiation
GO:0046651 ISS lymphocyte proliferation
GO:0046777 TAS protein autophosphorylation
GO:0071345 ISS cellular response to cytokine stimulus
GO:0071385 IEA cellular response to glucocorticoid stimulus
GO:0097028 ISS dendritic cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058503 flt3 fms-related tyrosine kinase 3 protein_coding Danio_rerio
ENSMUSG00000042817 Flt3 FMS-like tyrosine kinase 3 protein_coding Mus_musculus

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