C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: optineurin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000123240 OPTN 9606 + 10:13099449-13138308 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000263036 OPTN-006 13099449-13136923 protein_coding
  ENST00000378747 OPTN-008 13100225-13138291 protein_coding
  ENST00000378748 OPTN-005 13100173-13138291 protein_coding
  ENST00000378752 OPTN-004 13100173-13138291 protein_coding
  ENST00000378757 OPTN-007 13100169-13138308 protein_coding
  ENST00000378764 OPTN-009 13099603-13137129 protein_coding
  ENST00000424614 OPTN-001 13116268-13123198 protein_coding
  ENST00000430081 OPTN-011 13100173-13116327 nonsense_mediated_decay
  ENST00000469025 OPTN-003 13131319-13136918 processed_transcript
  ENST00000482140 OPTN-002 13100163-13118980 nonsense_mediated_decay
  ENST00000486862 OPTN-012 13112487-13116540 protein_coding
  ENST00000487935 OPTN-010 13100159-13109662 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263036ENST00000378747ENST00000378748ENST00000378752ENST00000378757ENST00000378764ENST00000424614
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263036 27.177±0.00 17.873±0.00 N/A 10.678±0.00 46.810±0.00 36.907±0.00 28.153±0.00 10.689±0.00 7.416±0.00 39.607±0.00 257.780±0.00 26.230±17.54 14.348±8.42 49.924±7.31
ENST00000378747 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.623±0.00 N/A N/A
ENST00000378748 N/A N/A N/A N/A N/A N/A N/A N/A 2.097±0.00 N/A N/A N/A N/A N/A
ENST00000378752 N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.740±0.00 N/A N/A N/A N/A
ENST00000378757 7.885±0.00 6.322±0.00 1.912±0.00 10.801±1.48 10.749±5.34 10.632±7.29 9.219±6.16 5.910±1.79 2.581±0.87 3.641±0.00 56.913±49.41 17.116±10.26 8.965±1.63 16.104±0.00
ENST00000378764 13.802±0.00 N/A 3.633±0.00 4.194±0.00 3.993±0.00 4.000±0.00 7.696±5.02 5.020±0.28 3.808±0.00 2.888±0.00 17.621±0.00 13.517±0.00 5.988±0.00 N/A
ENST00000424614 N/A N/A 20.612±0.00 40.607±0.00 29.392±0.00 18.861±0.00 15.300±0.00 23.885±0.00 27.740±0.00 22.193±0.00 62.802±0.00 41.072±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004RC CIL_0004RC_0002 CGP 10:12349482-13099652
CIL_0004RD CIL_0004RD_0002 CGP 10:12896625-13138308
CIL_000968 CIL_000968_0001 VISTA 10:13045564-13647145

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000042 IMP protein targeting to Golgi
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000139 TAS Golgi membrane
GO:0000278 TAS mitotic cell cycle
GO:0001920 IMP negative regulation of receptor recycling
GO:0005515 IPI protein binding
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005794 IDA Golgi apparatus
GO:0005802 IDA trans-Golgi network
GO:0005829 TAS cytosol
GO:0007030 IMP Golgi organization
GO:0007165 TAS signal transduction
GO:0008022 IPI protein C-terminus binding
GO:0008219 IEA cell death
GO:0016236 IDA macroautophagy
GO:0017137 IPI Rab GTPase binding
GO:0031410 IEA cytoplasmic vesicle
GO:0031593 IDA polyubiquitin binding
GO:0034613 IEA cellular protein localization
GO:0043001 IMP Golgi to plasma membrane protein transport
GO:0043124 IEA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050829 IMP defense response to Gram-negative bacterium
GO:0070530 IEA K63-linked polyubiquitin binding
GO:0090161 IDA Golgi ribbon formation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002663 optn optineurin protein_coding Danio_rerio
ENSMUSG00000026672 Optn optineurin protein_coding Mus_musculus

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