C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000124126 PREX1 9606 - 20:48624252-48827883 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000371941 PREX1-001 48624252-48827883 protein_coding
  ENST00000482556 PREX1-002 48624252-48657127 nonsense_mediated_decay
  ENST00000496915 PREX1-003 48642113-48642738 processed_transcript
  ENST00000620554 PREX1-004 48692323-48692684 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000371941ENST00000482556
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000371941 11.584±0.00 13.786±0.00 1.307±0.00 21.053±12.21 2.518±0.75 2.481±0.00 2.109±1.75 3.807±2.19 2.305±0.45 12.243±6.64 0.901±0.00 2.868±0.90 5.584±1.89 4.924±0.80
ENST00000482556 N/A 7.506±0.00 N/A 10.120±0.00 1.131±0.00 0.633±0.00 N/A N/A 0.563±0.00 3.858±0.00 N/A 1.629±0.21 1.992±0.54 1.870±0.24

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00025A CIL_00025A_0001 CGP 20:47656348-48827883

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005089 TAS:IEA Rho guanyl-nucleotide exchange factor activity
GO:0005100 TAS Rho GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005543 IDA phospholipid binding
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0005886 TAS plasma membrane
GO:0006801 TAS superoxide metabolic process
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0019899 TAS enzyme binding
GO:0030041 TAS actin filament polymerization
GO:0030217 IEA T cell differentiation
GO:0030426 IEA growth cone
GO:0030593 IEA neutrophil chemotaxis
GO:0030833 IEA regulation of actin filament polymerization
GO:0032855 IEA positive regulation of Rac GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0042119 TAS neutrophil activation
GO:0043198 IEA dendritic shaft
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045785 IEA positive regulation of cell adhesion
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050773 IEA regulation of dendrite development
GO:0072593 IEA reactive oxygen species metabolic process
GO:1900026 IEA positive regulation of substrate adhesion-dependent cell spreading

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075793 prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 protein_coding Danio_rerio
ENSMUSG00000039621 Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 protein_coding Mus_musculus

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