C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: runt-related transcription factor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000124813 RUNX2 9606 + 6:45328157-45664349 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359524 RUNX2-001 45422485-45551079 protein_coding
  ENST00000371432 RUNX2-201 45328317-45551082 protein_coding
  ENST00000371436 RUNX2-004 45328727-45547393 protein_coding
  ENST00000371438 RUNX2-003 45328369-45551079 protein_coding
  ENST00000465038 RUNX2-002 45328323-45547305 protein_coding
  ENST00000473041 RUNX2-006 45361573-45372055 processed_transcript
  ENST00000478660 RUNX2-009 45422036-45663872 nonsense_mediated_decay
  ENST00000483243 RUNX2-005 45328323-45372055 processed_transcript
  ENST00000483377 RUNX2-007 45328157-45547209 nonsense_mediated_decay
  ENST00000576263 RUNX2-008 45328727-45664349 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359524ENST00000371432ENST00000371436ENST00000371438ENST00000465038ENST00000478660ENST00000483243ENST00000576263
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359524 0.458±0.00 0.436±0.00 N/A 0.348±0.00 0.515±0.00 0.495±0.00 N/A 0.376±0.27 0.159±0.00 0.692±0.09 N/A 0.299±0.10 0.152±0.05 N/A
ENST00000371432 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.458±0.00 N/A 0.807±0.55 0.131±0.00 0.215±0.12
ENST00000371436 N/A N/A 0.222±0.00 0.486±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000371438 N/A N/A N/A N/A N/A 0.304±0.00 N/A N/A N/A N/A N/A 0.244±0.00 N/A N/A
ENST00000465038 N/A N/A N/A N/A N/A N/A 0.129±0.00 N/A N/A N/A N/A N/A N/A 0.571±0.00
ENST00000478660 N/A N/A N/A N/A N/A N/A N/A N/A 0.478±0.00 N/A N/A N/A N/A 0.393±0.00
ENST00000483243 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.928±0.00
ENST00000576263 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.197±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00028U CIL_00028U_0002 CGP 6:44387525-45377953
CIL_00028T CIL_00028T_0002 CGP 6:44809317-45664349
CIL_0007Z9 CIL_0007Z9_0001 VISTA 6:45132802-45734411
CIL_00082L CIL_00082L_0001 VISTA 6:45237622-45839555
CIL_00008A CIL_00008A_0003 CGP 6:45328157-46080395

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 ISS nuclear chromatin
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001501 IEA skeletal system development
GO:0001503 TAS ossification
GO:0001649 TAS osteoblast differentiation
GO:0001958 IEA endochondral ossification
GO:0002051 IEA osteoblast fate commitment
GO:0002062 IEA chondrocyte differentiation
GO:0002063 IEA chondrocyte development
GO:0002076 IEA osteoblast development
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005667 IEA transcription factor complex
GO:0005737 IEA cytoplasm
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0008284 IEA positive regulation of cell proliferation
GO:0010467 TAS gene expression
GO:0010628 IEA positive regulation of gene expression
GO:0019904 IEA protein domain specific binding
GO:0030217 IEA T cell differentiation
GO:0030278 IEA regulation of ossification
GO:0030509 ISS BMP signaling pathway
GO:0032332 IEA positive regulation of chondrocyte differentiation
GO:0035115 IEA embryonic forelimb morphogenesis
GO:0040036 IEA regulation of fibroblast growth factor receptor signaling pathway
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042487 IEA regulation of odontogenesis of dentin-containing tooth
GO:0043425 IEA bHLH transcription factor binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045667 IEA regulation of osteoblast differentiation
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045879 IEA negative regulation of smoothened signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048469 IEA cell maturation
GO:0048701 IEA embryonic cranial skeleton morphogenesis
GO:0048705 IEA skeletal system morphogenesis
GO:0048863 IEA stem cell differentiation
GO:0070491 IEA repressing transcription factor binding
GO:0071773 ISS cellular response to BMP stimulus
GO:1901522 ISS positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040261 runx2a runt-related transcription factor 2a protein_coding Danio_rerio
ENSDARG00000059233 runx2b runt-related transcription factor 2b protein_coding Danio_rerio
ENSMUSG00000039153 Runx2 runt related transcription factor 2 protein_coding Mus_musculus

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