C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CCR4-NOT transcription complex, subunit 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000125107 CNOT1 9606 - 16:58519951-58629886 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000245138 CNOT1-201 58519954-58532397 protein_coding
  ENST00000317147 CNOT1-001 58519951-58629886 protein_coding
  ENST00000441024 CNOT1-002 58543327-58629838 protein_coding
  ENST00000562046 CNOT1-022 58551790-58558490 protein_coding
  ENST00000563130 CNOT1-004 58520684-58533165 retained_intron
  ENST00000563283 CNOT1-012 58538158-58540066 retained_intron
  ENST00000564557 CNOT1-010 58588821-58629825 protein_coding
  ENST00000565605 CNOT1-020 58574717-58629832 nonsense_mediated_decay
  ENST00000565697 CNOT1-007 58599261-58624786 protein_coding
  ENST00000566240 CNOT1-018 58542230-58543802 nonsense_mediated_decay
  ENST00000567133 CNOT1-017 58543607-58546702 protein_coding
  ENST00000567188 CNOT1-005 58520706-58629832 nonsense_mediated_decay
  ENST00000567285 CNOT1-016 58546465-58551766 protein_coding
  ENST00000568158 CNOT1-009 58599374-58629815 processed_transcript
  ENST00000568917 CNOT1-019 58531958-58539878 protein_coding
  ENST00000569020 CNOT1-008 58599263-58629885 protein_coding
  ENST00000569240 CNOT1-003 58520695-58629834 protein_coding
  ENST00000569263 CNOT1-006 58623226-58629847 processed_transcript
  ENST00000569732 CNOT1-015 58551603-58558617 processed_transcript
  ENST00000569882 CNOT1-023 58555784-58575063 protein_coding
  ENST00000569916 CNOT1-011 58599010-58629824 retained_intron
  ENST00000569924 CNOT1-014 58521015-58525381 retained_intron
  ENST00000570139 CNOT1-013 58528614-58530668 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000245138ENST00000317147ENST00000441024ENST00000568917ENST00000569240
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000245138 7.708±0.00 16.678±0.00 N/A 6.105±1.25 13.309±0.00 15.776±0.00 11.392±0.00 22.174±0.00 7.023±0.00 16.222±0.00 14.829±0.00 17.226±0.45 15.666±3.23 44.067±0.00
ENST00000317147 3.330±0.00 N/A N/A 3.538±0.00 5.938±0.00 5.887±0.00 1.245±0.00 N/A 2.156±0.00 3.986±0.00 2.320±0.00 5.644±0.88 N/A 21.996±0.00
ENST00000441024 N/A N/A 8.800±0.00 2.801±0.00 7.656±0.00 6.622±0.00 1.559±0.00 6.670±0.00 4.883±0.00 5.766±0.00 N/A 4.182±0.00 N/A N/A
ENST00000568917 12.667±0.00 N/A N/A N/A 15.272±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 49.668±0.00
ENST00000569240 5.958±0.00 5.977±0.00 N/A 4.610±0.00 6.435±0.62 8.081±0.47 5.805±2.68 6.702±1.18 5.750±2.02 8.630±0.76 8.767±4.28 6.965±1.71 8.590±2.36 36.994±10.24

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004IY CIL_0004IY_0001 CGP 16:58462846-58521181
CIL_0004IZ CIL_0004IZ_0001 CGP 16:58515479-58629886

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000288 TAS nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 TAS nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 ISS cytoplasmic mRNA processing body
GO:0004535 IDA poly(A)-specific ribonuclease activity
GO:0005488 IEA binding
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0005634 IDA nucleus
GO:0005778 IDA peroxisomal membrane
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006417 IEA regulation of translation
GO:0010467 TAS gene expression
GO:0010606 IDA positive regulation of cytoplasmic mRNA processing body assembly
GO:0016020 IDA membrane
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0030014 IDA CCR4-NOT complex
GO:0030331 IDA estrogen receptor binding
GO:0031047 IEA gene silencing by RNA
GO:0033147 IDA negative regulation of intracellular estrogen receptor signaling pathway
GO:0042974 IDA retinoic acid receptor binding
GO:0044822 IDA poly(A) RNA binding
GO:0048387 IDA negative regulation of retinoic acid receptor signaling pathway
GO:0060213 IMP positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090503 IDA RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1900153 IMP positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000036 IMP regulation of stem cell maintenance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004174 cnot1 CCR4-NOT transcription complex, subunit 1 protein_coding Danio_rerio
ENSMUSG00000036550 Cnot1 CCR4-NOT transcription complex, subunit 1 protein_coding Mus_musculus

Loading