C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SIX homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000126778 SIX1 9606 - 14:60643415-60658259 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000247182 SIX1-001 60643415-60649462 protein_coding
  ENST00000553535 SIX1-002 60645270-60653026 processed_transcript
  ENST00000554986 SIX1-005 60644696-60658259 protein_coding
  ENST00000555627 SIX1-003 60651775-60653079 retained_intron
  ENST00000555955 SIX1-004 60644931-60653131 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000247182ENST00000553535ENST00000554986
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000247182 0.685±0.00 N/A 0.045±0.01 0.558±0.43 N/A N/A N/A 0.239±0.00 0.612±0.34 4.117±2.89 0.389±0.24 0.025±0.01 0.622±0.31
ENST00000553535 0.412±0.00 0.213±0.00 0.089±0.08 3.272±0.00 0.067±0.00 0.021±0.00 N/A N/A 1.619±0.00 6.749±5.43 0.363±0.32 0.022±0.02 1.201±0.00
ENST00000554986 1.292±0.00 0.060±0.00 N/A 1.107±0.73 N/A 0.015±0.00 0.083±0.00 N/A 1.200±0.00 5.405±3.54 0.683±0.78 0.045±0.01 2.000±1.04

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MW CIL_0008MW_0001 VISTA 14:60353481-60955733
CIL_00036B CIL_00036B_0002 CGP 14:60508951-60658259
CIL_0006SM CIL_0006SM_0002 CGP 14:60643415-60724348

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001657 ISS ureteric bud development
GO:0001658 ISS branching involved in ureteric bud morphogenesis
GO:0001759 ISS organ induction
GO:0001822 ISS kidney development
GO:0003151 IEA outflow tract morphogenesis
GO:0003677 IDA:IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 ISS sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 ISS transcription factor complex
GO:0005730 IDA nucleolus
GO:0005737 IEA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 ISS regulation of transcription, DNA-templated
GO:0006915 IEA apoptotic process
GO:0007389 ISS pattern specification process
GO:0007519 ISS skeletal muscle tissue development
GO:0007605 IEA sensory perception of sound
GO:0008582 IEA regulation of synaptic growth at neuromuscular junction
GO:0010468 IEA regulation of gene expression
GO:0014842 IEA regulation of satellite cell proliferation
GO:0021610 IEA facial nerve morphogenesis
GO:0022008 IEA neurogenesis
GO:0030855 ISS epithelial cell differentiation
GO:0030878 ISS thyroid gland development
GO:0030910 IEA olfactory placode formation
GO:0032880 IEA regulation of protein localization
GO:0034504 IDA protein localization to nucleus
GO:0035909 IEA aorta morphogenesis
GO:0042472 ISS inner ear morphogenesis
GO:0042474 IEA middle ear morphogenesis
GO:0043066 IEA negative regulation of apoptotic process
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0043586 IEA tongue development
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045664 ISS regulation of neuron differentiation
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048538 ISS thymus development
GO:0048665 IEA neuron fate specification
GO:0048699 ISS generation of neurons
GO:0048701 ISS embryonic cranial skeleton morphogenesis
GO:0048704 ISS embryonic skeletal system morphogenesis
GO:0048705 IEA skeletal system morphogenesis
GO:0048839 ISS inner ear development
GO:0048856 IEA anatomical structure development
GO:0050678 IEA regulation of epithelial cell proliferation
GO:0051451 ISS myoblast migration
GO:0060037 IEA pharyngeal system development
GO:0061055 IEA myotome development
GO:0061197 IEA fungiform papilla morphogenesis
GO:0061551 IEA trigeminal ganglion development
GO:0071599 IEA otic vesicle development
GO:0072001 IEA renal system development
GO:0072075 ISS metanephric mesenchyme development
GO:0072095 ISS regulation of branch elongation involved in ureteric bud branching
GO:0072107 ISS positive regulation of ureteric bud formation
GO:0072172 ISS mesonephric tubule formation
GO:0072193 IEA ureter smooth muscle cell differentiation
GO:0072513 IEA positive regulation of secondary heart field cardioblast proliferation
GO:0090103 IEA cochlea morphogenesis
GO:0090190 ISS positive regulation of branching involved in ureteric bud morphogenesis
GO:0090191 IEA negative regulation of branching involved in ureteric bud morphogenesis
GO:2000729 IEA positive regulation of mesenchymal cell proliferation involved in ureter development
GO:2001014 IEA regulation of skeletal muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000026473 six1b sine oculis homeobox homolog 1b protein_coding Danio_rerio
ENSDARG00000039304 six1a sine oculis homeobox homolog 1a protein_coding Danio_rerio
ENSMUSG00000051367 Six1 sine oculis-related homeobox 1 protein_coding Mus_musculus

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