C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000126934 MAP2K2 9606 - 19:4090321-4124129 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262948 MAP2K2-001 4090321-4124129 protein_coding
  ENST00000394867 MAP2K2-201 4090333-4124117 protein_coding
  ENST00000593364 MAP2K2-005 4099195-4103213 processed_transcript
  ENST00000595715 MAP2K2-006 4095388-4100072 processed_transcript
  ENST00000597008 MAP2K2-007 4100459-4102504 retained_intron
  ENST00000597263 MAP2K2-011 4090434-4101272 processed_transcript
  ENST00000599021 MAP2K2-010 4090597-4101047 protein_coding
  ENST00000599345 MAP2K2-009 4101071-4124072 processed_transcript
  ENST00000600584 MAP2K2-004 4090324-4100679 retained_intron
  ENST00000601786 MAP2K2-003 4090324-4103204 retained_intron
  ENST00000602167 MAP2K2-008 4099409-4104792 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262948ENST00000394867ENST00000595715ENST00000599345
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262948 8.999±0.00 23.253±0.00 4.803±0.00 13.660±9.57 12.515±6.73 19.304±10.84 19.723±16.40 15.571±4.80 15.651±12.17 17.390±14.44 46.688±15.44 36.620±22.25 55.045±24.36 89.488±41.70
ENST00000394867 50.161±0.00 45.421±0.00 N/A 19.876±10.25 46.338±0.00 22.523±15.11 4.954±2.00 32.213±0.00 18.472±0.00 12.090±0.00 21.463±4.29 23.941±19.05 44.659±6.38 60.922±0.00
ENST00000595715 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.386±0.00 N/A N/A N/A N/A
ENST00000599345 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 64.125±0.00 113.875±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005QS CIL_0005QS_0002 CGP 19:4044364-4124129

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 TAS MAPK cascade
GO:0000186 TAS activation of MAPKK activity
GO:0000187 TAS activation of MAPK activity
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 IEA:TAS protein serine/threonine kinase activity
GO:0004708 IDA MAP kinase kinase activity
GO:0004712 TAS protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005576 NAS extracellular region
GO:0005634 TAS nucleus
GO:0005737 IDA cytoplasm
GO:0005739 TAS mitochondrion
GO:0005769 TAS early endosome
GO:0005770 TAS late endosome
GO:0005778 IDA peroxisomal membrane
GO:0005783 IDA endoplasmic reticulum
GO:0005794 TAS Golgi apparatus
GO:0005829 TAS cytosol
GO:0005874 IDA microtubule
GO:0005911 IDA cell-cell junction
GO:0005925 TAS focal adhesion
GO:0005938 IEA cell cortex
GO:0006468 IEA protein phosphorylation
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007411 TAS axon guidance
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009898 IDA cytoplasmic side of plasma membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030165 IDA PDZ domain binding
GO:0032872 TAS regulation of stress-activated MAPK cascade
GO:0032947 IEA protein complex scaffold
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0036289 IDA peptidyl-serine autophosphorylation
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043539 IDA protein serine/threonine kinase activator activity
GO:0045087 TAS innate immune response
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051403 TAS stress-activated MAPK cascade
GO:0070371 TAS ERK1 and ERK2 cascade
GO:0071902 IDA positive regulation of protein serine/threonine kinase activity
GO:0090170 TAS regulation of Golgi inheritance
GO:0097110 IPI scaffold protein binding
GO:2000147 IEA positive regulation of cell motility
GO:2000641 TAS regulation of early endosome to late endosome transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006609 map2k2a mitogen-activated protein kinase kinase 2a protein_coding Danio_rerio
ENSDARG00000068918 map2k2b mitogen-activated protein kinase kinase 2b protein_coding Danio_rerio
ENSMUSG00000035027 Map2k2 mitogen-activated protein kinase kinase 2 protein_coding Mus_musculus

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