C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000127241 MASP1 9606 - 3:187217285-187292022 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000169293 MASP1-002 187246361-187291957 protein_coding
  ENST00000296280 MASP1-003 187234082-187291858 protein_coding
  ENST00000337774 MASP1-001 187217285-187292022 protein_coding
  ENST00000392470 MASP1-004 187247159-187291882 protein_coding
  ENST00000392472 MASP1-005 187234084-187291977 protein_coding
  ENST00000392475 MASP1-007 187256815-187291980 protein_coding
  ENST00000425937 MASP1-010 187262714-187291697 protein_coding
  ENST00000439271 MASP1-008 187262681-187291958 protein_coding
  ENST00000460839 MASP1-011 187256585-187286008 retained_intron
  ENST00000465015 MASP1-012 187260770-187276821 processed_transcript
  ENST00000468121 MASP1-014 187226227-187243585 processed_transcript
  ENST00000480349 MASP1-006 187234082-187244976 retained_intron
  ENST00000483719 MASP1-015 187251377-187253201 retained_intron
  ENST00000490558 MASP1-013 187256800-187263256 processed_transcript
  ENST00000495249 MASP1-009 187235867-187291754 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000169293ENST00000296280ENST00000337774ENST00000392470ENST00000392472ENST00000460839ENST00000480349ENST00000495249
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000169293 N/A N/A N/A N/A 0.808±0.00 N/A 13.227±10.75 N/A N/A N/A 2.250±0.00 0.077±0.00 N/A N/A
ENST00000296280 0.403±0.00 0.130±0.00 N/A 2.682±2.27 1.569±0.68 4.799±3.60 N/A 4.293±3.80 4.507±3.74 2.489±1.46 N/A 1.321±0.59 6.243±1.67 0.502±0.39
ENST00000337774 0.054±0.00 N/A 0.150±0.00 N/A N/A N/A N/A 12.190±0.00 7.203±0.00 N/A N/A 0.155±0.00 0.525±0.00 N/A
ENST00000392470 N/A N/A 0.222±0.00 N/A N/A N/A 16.416±0.00 N/A N/A N/A N/A 0.558±0.30 N/A N/A
ENST00000392472 N/A 0.354±0.00 N/A 3.071±0.00 N/A N/A 0.653±0.00 N/A N/A N/A N/A 0.163±0.04 N/A N/A
ENST00000460839 N/A N/A N/A N/A N/A N/A 4.316±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000480349 N/A 0.094±0.00 0.055±0.00 N/A N/A 0.168±0.00 N/A N/A 0.175±0.00 0.109±0.00 N/A N/A N/A N/A
ENST00000495249 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.465±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008LA CIL_0008LA_0001 VISTA 3:186647123-187250687
CIL_000047 CIL_000047_0001 CGP 3:187217285-187372076

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001867 IMP complement activation, lectin pathway
GO:0003824 IEA catalytic activity
GO:0004252 IDA serine-type endopeptidase activity
GO:0005509 IEA:IDA calcium ion binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0006508 IEA proteolysis
GO:0006956 TAS complement activation
GO:0008233 IDA peptidase activity
GO:0042803 IPI protein homodimerization activity
GO:0045087 TAS innate immune response
GO:0045916 IDA negative regulation of complement activation
GO:0048306 IPI calcium-dependent protein binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068726 masp1 mannan-binding lectin serine peptidase 1 protein_coding Danio_rerio
ENSMUSG00000022887 Masp1 mannan-binding lectin serine peptidase 1 protein_coding Mus_musculus

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