C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: TNF receptor-associated factor 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000131323 TRAF3 9606 + 14:102777476-102911500 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000347662 TRAF3-201 102777479-102911499 protein_coding
  ENST00000351691 TRAF3-004 102830354-102906255 protein_coding
  ENST00000392745 TRAF3-005 102777557-102906261 protein_coding
  ENST00000539721 TRAF3-002 102777602-102906021 protein_coding
  ENST00000558700 TRAF3-007 102871927-102897307 nonsense_mediated_decay
  ENST00000558880 TRAF3-009 102875675-102876677 retained_intron
  ENST00000559734 TRAF3-008 102875687-102905463 protein_coding
  ENST00000560371 TRAF3-001 102777476-102911500 protein_coding
  ENST00000560463 TRAF3-006 102777618-102871953 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000347662ENST00000351691ENST00000392745ENST00000539721ENST00000558700ENST00000558880ENST00000559734ENST00000560371
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000347662 N/A 3.230±0.00 0.333±0.00 1.160±0.00 0.876±0.00 1.307±0.00 0.895±0.00 0.616±0.00 N/A N/A 0.415±0.00 0.524±0.06 0.623±0.00 N/A
ENST00000351691 N/A N/A N/A 1.744±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000392745 N/A N/A N/A N/A 1.911±0.00 2.738±0.00 0.227±0.00 1.287±0.00 1.453±0.00 1.152±0.00 N/A 1.171±0.00 N/A N/A
ENST00000539721 1.205±0.00 N/A N/A N/A N/A N/A 0.273±0.00 N/A N/A 1.876±0.00 0.272±0.00 1.562±0.34 1.523±0.00 5.008±0.00
ENST00000558700 N/A N/A 3.554±0.00 N/A N/A N/A N/A 1.601±0.00 N/A N/A 0.569±0.00 N/A N/A N/A
ENST00000558880 N/A N/A 22.314±0.00 19.107±0.00 9.296±0.00 N/A N/A 4.085±0.00 14.022±0.00 15.328±0.00 N/A 11.090±0.00 N/A N/A
ENST00000559734 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.754±0.00 2.981±0.00 8.011±0.00
ENST00000560371 1.642±0.00 4.929±0.00 0.503±0.00 1.187±0.48 1.712±1.13 0.802±0.00 1.700±0.00 1.317±0.00 0.980±0.21 1.612±0.70 N/A 2.042±0.61 1.282±0.57 1.105±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009AG CIL_0009AG_0001 VISTA 14:102447254-103047442
CIL_00040T CIL_00040T_0001 CGP 14:102777476-102933596

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001817 IEA regulation of cytokine production
GO:0002224 ISS toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004842 IEA ubiquitin-protein transferase activity
GO:0004871 TAS signal transducer activity
GO:0005164 IPI tumor necrosis factor receptor binding
GO:0005515 IEA protein binding
GO:0005739 IEA mitochondrion
GO:0005768 IEA endosome
GO:0005829 TAS cytosol
GO:0006915 IEA apoptotic process
GO:0007165 IEA signal transduction
GO:0008063 IEA Toll signaling pathway
GO:0008270 IEA zinc ion binding
GO:0009898 ISS cytoplasmic side of plasma membrane
GO:0016567 IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019901 IEA protein kinase binding
GO:0030162 IMP regulation of proteolysis
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031996 IPI thioesterase binding
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0032480 TAS negative regulation of type I interferon production
GO:0032648 ISS regulation of interferon-beta production
GO:0033209 IEA tumor necrosis factor-mediated signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0035631 ISS CD40 receptor complex
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0042981 IEA regulation of apoptotic process
GO:0045087 IEA innate immune response
GO:0050688 IEA regulation of defense response to virus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022000 traf3 TNF receptor-associated factor 3 protein_coding Danio_rerio
ENSMUSG00000021277 Traf3 TNF receptor-associated factor 3 protein_coding Mus_musculus

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