C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear receptor subfamily 1, group H, member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000131408 NR1H2 9606 + 19:50329653-50382982 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000253727 NR1H2-001 50376469-50382982 protein_coding
  ENST00000411902 NR1H2-003 50376459-50382731 protein_coding
  ENST00000593532 NR1H2-010 50329692-50382979 nonsense_mediated_decay
  ENST00000593926 NR1H2-002 50377245-50382944 protein_coding
  ENST00000595730 NR1H2-007 50376457-50378155 retained_intron
  ENST00000597085 NR1H2-013 50378741-50382298 retained_intron
  ENST00000597130 NR1H2-008 50376473-50378678 protein_coding
  ENST00000597157 NR1H2-009 50377434-50378733 protein_coding
  ENST00000597790 NR1H2-006 50376473-50378312 protein_coding
  ENST00000598168 NR1H2-014 50376458-50382978 protein_coding
  ENST00000599105 NR1H2-005 50376473-50382950 protein_coding
  ENST00000600355 NR1H2-011 50329653-50377811 protein_coding
  ENST00000600978 NR1H2-012 50329722-50371440 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000253727ENST00000411902ENST00000593926ENST00000597157ENST00000598168ENST00000599105
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000253727 33.558±0.00 40.969±0.00 N/A 17.564±9.63 28.526±0.00 25.202±20.06 15.682±13.71 18.230±15.36 13.340±7.28 25.240±21.71 29.712±17.26 46.176±8.31 56.776±5.56 45.434±0.00
ENST00000411902 14.772±0.00 12.566±0.00 N/A N/A 8.900±0.00 N/A 0.624±0.00 N/A N/A N/A N/A 4.281±0.00 N/A 10.733±0.00
ENST00000593926 N/A N/A 0.530±0.00 N/A 3.454±0.00 N/A N/A 2.471±0.00 N/A N/A N/A 9.197±0.00 27.331±0.00 26.548±0.00
ENST00000597157 N/A N/A 4.417±0.00 N/A N/A N/A N/A N/A N/A 1.653±0.00 N/A N/A N/A N/A
ENST00000598168 N/A N/A N/A 1.091±0.00 N/A N/A 0.444±0.00 1.029±0.00 0.958±0.00 N/A N/A 0.625±0.00 N/A N/A
ENST00000599105 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.912±0.00 27.486±0.00 17.885±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004IL CIL_0004IL_0001 CGP 19:50329653-50382982

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001133 IEA sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
GO:0003677 TAS DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IEA:IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0008270 IEA zinc ion binding
GO:0010467 TAS gene expression
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010745 IC negative regulation of macrophage derived foam cell differentiation
GO:0010867 IMP positive regulation of triglyceride biosynthetic process
GO:0010875 IMP positive regulation of cholesterol efflux
GO:0010884 IEA positive regulation of lipid storage
GO:0010887 IMP negative regulation of cholesterol storage
GO:0030522 IEA intracellular receptor signaling pathway
GO:0032270 IMP positive regulation of cellular protein metabolic process
GO:0032369 IMP negative regulation of lipid transport
GO:0032376 IDA positive regulation of cholesterol transport
GO:0034191 IPI apolipoprotein A-I receptor binding
GO:0042632 IEA cholesterol homeostasis
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0044255 IEA cellular lipid metabolic process
GO:0045723 IMP positive regulation of fatty acid biosynthetic process
GO:0045861 IEA negative regulation of proteolysis
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046965 IEA retinoid X receptor binding
GO:0048384 IEA retinoic acid receptor signaling pathway
GO:0048550 IMP negative regulation of pinocytosis
GO:0051006 IMP positive regulation of lipoprotein lipase activity
GO:0051117 IPI ATPase binding
GO:0055088 IEA lipid homeostasis
GO:0060336 NAS negative regulation of interferon-gamma-mediated signaling pathway
GO:0090108 IEA positive regulation of high-density lipoprotein particle assembly
GO:0090187 IEA positive regulation of pancreatic juice secretion
GO:0090340 IEA positive regulation of secretion of lysosomal enzymes
GO:2000188 ISS regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000060601 Nr1h2 nuclear receptor subfamily 1, group H, member 2 protein_coding Mus_musculus

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