C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: receptor (G protein-coupled) activity modifying protein 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000131477 RAMP2 9606 + 17:42758447-42763041 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000253796 RAMP2-001 42761194-42763036 protein_coding
  ENST00000587142 RAMP2-002 42761258-42762854 protein_coding
  ENST00000588576 RAMP2-003 42761258-42763002 protein_coding
  ENST00000588928 RAMP2-005 42760805-42762698 protein_coding
  ENST00000589683 RAMP2-004 42760775-42763041 protein_coding
  ENST00000591972 RAMP2-006 42758447-42761899 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000253796ENST00000587142ENST00000588576ENST00000589683
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000253796 110.073±0.00 70.304±0.00 N/A 4.234±3.08 28.847±27.14 10.290±8.90 7.798±6.74 14.828±0.00 3.742±0.00 39.705±35.35 9.097±0.00 26.115±10.84 114.925±52.21 10.953±3.90
ENST00000587142 N/A 29.700±0.00 N/A N/A 19.916±0.00 7.704±0.00 N/A 9.611±0.00 N/A N/A N/A N/A N/A 9.965±0.00
ENST00000588576 N/A N/A 0.692±0.00 2.547±0.00 3.779±0.00 N/A 7.319±0.00 3.827±0.00 1.736±0.00 14.986±11.42 2.588±0.67 8.101±4.86 62.620±0.84 N/A
ENST00000589683 N/A N/A 0.986±0.00 N/A N/A N/A 0.792±0.00 N/A 1.181±0.22 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004IN CIL_0004IN_0001 CGP 17:42700275-42763041
CIL_0004JZ CIL_0004JZ_0001 CGP 17:42758447-42779599

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IDA angiogenesis
GO:0001570 IMP vasculogenesis
GO:0001666 IEA response to hypoxia
GO:0002040 ISS sprouting angiogenesis
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005764 TAS lysosome
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0005905 TAS coated pit
GO:0006171 IDA cAMP biosynthetic process
GO:0006816 IDA calcium ion transport
GO:0006886 IEA intracellular protein transport
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007507 ISS heart development
GO:0007565 IEA female pregnancy
GO:0008217 ISS regulation of blood pressure
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0008565 IEA:IDA protein transporter activity
GO:0009986 IDA cell surface
GO:0010628 IDA positive regulation of gene expression
GO:0015026 ISS coreceptor activity
GO:0015031 IDA protein transport
GO:0016021 IEA integral component of membrane
GO:0030819 IDA positive regulation of cAMP biosynthetic process
GO:0031623 IDA receptor internalization
GO:0032355 IEA response to estradiol
GO:0032570 IEA response to progesterone
GO:0032870 IEA cellular response to hormone stimulus
GO:0034333 IDA adherens junction assembly
GO:0035924 ISS cellular response to vascular endothelial growth factor stimulus
GO:0043116 IDA negative regulation of vascular permeability
GO:0043235 IDA receptor complex
GO:0045766 ISS positive regulation of angiogenesis
GO:0070830 IDA tight junction assembly
GO:0070831 ISS basement membrane assembly
GO:0072659 IDA protein localization to plasma membrane
GO:0097084 ISS vascular smooth muscle cell development
GO:2000352 IDA negative regulation of endothelial cell apoptotic process
GO:2001214 IEA positive regulation of vasculogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000087020 receptor (G protein-coupled) activity modifying protein 2 protein_coding Danio_rerio
ENSMUSG00000001240 Ramp2 receptor (calcitonin) activity modifying protein 2 protein_coding Mus_musculus

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