C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho guanine nucleotide exchange factor (GEF) 11
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000132694 ARHGEF11 9606 - 1:156934840-157045370 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000361409 ARHGEF11-002 156935524-157045073 protein_coding
  ENST00000368194 ARHGEF11-001 156934840-157045370 protein_coding
  ENST00000461678 ARHGEF11-006 156945908-156947378 processed_transcript
  ENST00000483682 ARHGEF11-004 156967911-156971825 processed_transcript
  ENST00000486670 ARHGEF11-005 156955724-156963766 processed_transcript
  ENST00000487682 ARHGEF11-003 156934845-156945631 processed_transcript
  ENST00000492592 ARHGEF11-007 156936816-156939740 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361409ENST00000368194ENST00000486670ENST00000487682
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361409 3.756±0.00 1.758±0.00 1.338±0.00 3.319±1.44 3.534±1.03 2.203±1.00 1.027±0.41 1.419±0.32 1.171±0.00 1.989±0.09 1.154±0.00 4.724±2.98 0.926±0.00 3.781±0.28
ENST00000368194 1.971±0.00 N/A N/A 2.802±0.74 3.016±0.00 N/A 1.567±0.00 N/A 0.873±0.01 N/A 2.321±0.00 3.140±0.43 0.735±0.00 1.982±0.00
ENST00000486670 N/A N/A N/A N/A N/A 7.208±0.00 3.343±0.00 2.456±0.00 5.171±0.00 N/A N/A 14.444±0.00 N/A N/A
ENST00000487682 N/A 1.507±0.00 N/A 1.798±0.00 1.322±0.00 0.987±0.22 N/A 0.373±0.00 N/A 0.794±0.05 N/A 2.255±0.00 N/A 3.326±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000850 CIL_000850_0001 VISTA 1:156360457-156965492

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000910 NAS cytokinesis
GO:0001558 NAS regulation of cell growth
GO:0001664 IDA G-protein coupled receptor binding
GO:0005089 TAS:IEA Rho guanyl-nucleotide exchange factor activity
GO:0005096 IEA GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005622 IC intracellular
GO:0005737 IDA:IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006928 NAS cellular component movement
GO:0006941 NAS striated muscle contraction
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007266 IDA Rho protein signal transduction
GO:0007411 TAS axon guidance
GO:0008277 IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0016020 IEA membrane
GO:0030010 NAS establishment of cell polarity
GO:0030036 NAS actin cytoskeleton organization
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway
GO:0043065 TAS positive regulation of apoptotic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052482 arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 protein_coding Danio_rerio
ENSMUSG00000041977 Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 protein_coding Mus_musculus

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