C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hydroxysteroid (17-beta) dehydrogenase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000133835 HSD17B4 9606 + 5:119452443-119637199 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000256216 HSD17B4-001 119452443-119542333 protein_coding
  ENST00000414835 HSD17B4-004 119452753-119542332 protein_coding
  ENST00000442060 HSD17B4-009 119452497-119542332 nonsense_mediated_decay
  ENST00000503168 HSD17B4-013 119452775-119478999 retained_intron
  ENST00000503310 HSD17B4-024 119535770-119542252 retained_intron
  ENST00000504811 HSD17B4-003 119452570-119542264 protein_coding
  ENST00000505181 HSD17B4-018 119476448-119489283 processed_transcript
  ENST00000507353 HSD17B4-023 119525736-119530100 retained_intron
  ENST00000507695 HSD17B4-016 119456313-119475873 retained_intron
  ENST00000508750 HSD17B4-012 119452766-119456732 retained_intron
  ENST00000508788 HSD17B4-019 119476571-119478943 processed_transcript
  ENST00000509514 HSD17B4-006 119476629-119542252 protein_coding
  ENST00000509606 HSD17B4-020 119527158-119542332 retained_intron
  ENST00000509951 HSD17B4-011 119525258-119542331 processed_transcript
  ENST00000510025 HSD17B4-005 119452538-119542269 protein_coding
  ENST00000511186 HSD17B4-015 119452473-119477489 retained_intron
  ENST00000512029 HSD17B4-022 119496556-119499638 retained_intron
  ENST00000512644 HSD17B4-021 119478832-119492124 retained_intron
  ENST00000512841 HSD17B4-025 119452716-119478935 processed_transcript
  ENST00000513628 HSD17B4-007 119476542-119542174 protein_coding
  ENST00000515235 HSD17B4-008 119452516-119637199 retained_intron
  ENST00000515320 HSD17B4-002 119452497-119542252 protein_coding
  ENST00000518349 HSD17B4-028 119496541-119526024 processed_transcript
  ENST00000519184 HSD17B4-026 119452565-119473980 processed_transcript
  ENST00000520216 HSD17B4-027 119493818-119502080 processed_transcript
  ENST00000520244 HSD17B4-030 119502049-119526009 processed_transcript
  ENST00000522415 HSD17B4-029 119509141-119542016 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000256216ENST00000414835ENST00000503168ENST00000509606ENST00000510025ENST00000512644ENST00000513628ENST00000515235ENST00000515320ENST00000522415
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000256216 N/A 9.091±0.00 9.739±0.00 9.178±1.02 11.017±5.05 9.879±0.57 13.959±1.55 30.631±19.57 8.819±0.00 13.620±4.84 5.647±0.00 16.933±2.74 23.703±2.78 7.346±0.00
ENST00000414835 14.398±0.00 N/A N/A N/A 6.890±0.00 N/A 6.641±0.00 N/A N/A N/A N/A 5.897±0.00 N/A 11.798±0.00
ENST00000503168 N/A N/A N/A 40.044±0.00 N/A N/A N/A N/A N/A N/A N/A 4.924±0.00 16.313±0.00 N/A
ENST00000509606 N/A N/A N/A 18.382±0.00 N/A N/A N/A 26.846±0.00 67.561±0.00 N/A N/A 23.934±0.00 N/A N/A
ENST00000510025 N/A N/A N/A N/A N/A N/A N/A N/A 4.156±0.00 N/A N/A N/A N/A 6.228±0.00
ENST00000512644 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 30.275±0.00 N/A N/A N/A
ENST00000513628 N/A N/A N/A 8.400±0.00 N/A N/A N/A N/A N/A N/A N/A 1.598±0.00 N/A N/A
ENST00000515235 N/A N/A N/A 2.439±0.00 N/A 2.119±0.00 N/A 6.567±0.00 2.863±0.00 N/A N/A N/A N/A N/A
ENST00000515320 28.060±0.00 10.615±0.00 N/A 16.852±0.00 19.392±0.00 11.476±0.00 20.843±0.00 28.308±0.00 54.639±0.00 13.794±0.00 6.064±0.65 3.003±0.00 N/A 14.784±8.23
ENST00000522415 N/A N/A N/A 27.328±0.00 21.208±0.00 17.990±1.98 N/A 32.542±0.00 57.173±0.00 20.407±0.00 N/A 10.276±6.89 18.534±6.42 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004LE CIL_0004LE_0001 CGP 5:119268692-119637199
CIL_0004B4 CIL_0004B4_0001 CGP 5:119452443-119637199

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000038 IEA very long-chain fatty acid metabolic process
GO:0001649 IDA osteoblast differentiation
GO:0003857 IDA 3-hydroxyacyl-CoA dehydrogenase activity
GO:0005102 IPI receptor binding
GO:0005739 IEA mitochondrion
GO:0005777 IDA peroxisome
GO:0005778 IDA peroxisomal membrane
GO:0005782 TAS peroxisomal matrix
GO:0006635 IDA fatty acid beta-oxidation
GO:0006699 TAS bile acid biosynthetic process
GO:0008152 IDA:IEA metabolic process
GO:0008206 TAS bile acid metabolic process
GO:0008209 IDA androgen metabolic process
GO:0008210 IDA estrogen metabolic process
GO:0016020 IDA membrane
GO:0016491 IEA oxidoreductase activity
GO:0016508 IDA long-chain-enoyl-CoA hydratase activity
GO:0016853 IEA isomerase activity
GO:0033540 TAS fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033559 TAS unsaturated fatty acid metabolic process
GO:0033989 TAS 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
GO:0036109 TAS alpha-linolenic acid metabolic process
GO:0036111 IDA very long-chain fatty-acyl-CoA metabolic process
GO:0036112 IDA medium-chain fatty-acyl-CoA metabolic process
GO:0042803 IDA protein homodimerization activity
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0044594 IDA 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO:0055114 IEA:IDA oxidation-reduction process
GO:0060009 IEA Sertoli cell development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031873 hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 protein_coding Danio_rerio
ENSMUSG00000024507 Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 protein_coding Mus_musculus

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