C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: multiple endocrine neoplasia I
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000133895 MEN1 9606 - 11:64803510-64811294 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000312049 MEN1-001 64803516-64810716 protein_coding
  ENST00000315422 MEN1-003 64803516-64810741 protein_coding
  ENST00000337652 MEN1-201 64803524-64811294 protein_coding
  ENST00000377313 MEN1-011 64804334-64810132 protein_coding
  ENST00000377316 MEN1-008 64803510-64810485 protein_coding
  ENST00000377321 MEN1-002 64803516-64810558 protein_coding
  ENST00000377326 MEN1-007 64803516-64810608 protein_coding
  ENST00000394374 MEN1-202 64803524-64810741 protein_coding
  ENST00000394376 MEN1-203 64803524-64811294 protein_coding
  ENST00000413626 MEN1-010 64807552-64810521 protein_coding
  ENST00000424912 MEN1-006 64809670-64811294 protein_coding
  ENST00000429702 MEN1-005 64809670-64811294 protein_coding
  ENST00000440873 MEN1-009 64806242-64810558 protein_coding
  ENST00000450708 MEN1-004 64807080-64810581 protein_coding
  ENST00000478548 MEN1-012 64804375-64806368 retained_intron
  ENST00000487019 MEN1-013 64805126-64805992 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000312049ENST00000315422ENST00000377313ENST00000377316ENST00000377321ENST00000377326ENST00000394374ENST00000413626ENST00000424912ENST00000440873ENST00000450708ENST00000478548ENST00000487019
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000312049 5.169±0.00 4.155±0.00 N/A 3.290±2.31 5.160±0.00 4.703±0.00 0.466±0.37 11.627±0.00 4.677±0.00 4.524±0.00 4.712±0.00 9.738±3.26 11.889±2.79 7.070±1.98
ENST00000315422 1.134±0.00 2.113±0.00 N/A 0.940±0.44 2.243±1.03 1.177±0.00 N/A N/A N/A 0.789±0.41 N/A 5.463±4.25 2.299±0.76 2.417±0.00
ENST00000377313 N/A N/A 1.435±0.00 N/A N/A 0.576±0.00 0.322±0.00 2.154±0.00 N/A 0.424±0.00 N/A 1.270±0.00 N/A N/A
ENST00000377316 N/A N/A 0.616±0.00 N/A N/A N/A N/A N/A 1.630±0.00 2.027±0.00 N/A 0.372±0.00 N/A N/A
ENST00000377321 1.054±0.00 2.233±0.00 N/A N/A N/A 1.041±0.01 1.990±0.00 N/A 1.020±0.53 1.396±0.00 2.085±0.18 2.057±0.34 N/A 2.037±0.29
ENST00000377326 0.803±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000394374 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.388±0.00 N/A 1.960±0.00 N/A N/A
ENST00000413626 N/A N/A N/A N/A N/A 3.456±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000424912 N/A N/A 11.205±0.00 2.364±0.00 N/A N/A N/A N/A 0.987±0.00 1.095±0.00 N/A 2.511±0.00 N/A N/A
ENST00000440873 N/A N/A N/A 0.750±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000450708 N/A N/A N/A N/A 1.242±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000478548 N/A N/A N/A N/A N/A N/A 0.159±0.00 N/A 0.570±0.00 N/A N/A N/A N/A N/A
ENST00000487019 N/A N/A N/A N/A N/A N/A N/A N/A 1.773±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005JE CIL_0005JE_0002 CGP 11:64788818-64811294

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000165 IDA MAPK cascade
GO:0000400 IDA four-way junction DNA binding
GO:0000403 IDA Y-form DNA binding
GO:0000785 IDA chromatin
GO:0001503 IEA ossification
GO:0001776 IEA leukocyte homeostasis
GO:0001933 IDA negative regulation of protein phosphorylation
GO:0002051 IEA osteoblast fate commitment
GO:0002076 IGI osteoblast development
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003690 IDA double-stranded DNA binding
GO:0005515 IPI protein binding
GO:0005634 IEA:IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006281 NAS DNA repair
GO:0006338 IEA chromatin remodeling
GO:0006351 TAS transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007050 IEA cell cycle arrest
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007420 IEA brain development
GO:0008285 IDA negative regulation of cell proliferation
GO:0009411 IDA response to UV
GO:0010332 IDA response to gamma radiation
GO:0010467 TAS gene expression
GO:0016363 IDA nuclear matrix
GO:0016571 IEA histone methylation
GO:0018024 IDA histone-lysine N-methyltransferase activity
GO:0030097 IEA hemopoiesis
GO:0030511 IMP positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030674 IDA protein binding, bridging
GO:0031062 IEA positive regulation of histone methylation
GO:0032092 IDA positive regulation of protein binding
GO:0032154 IDA cleavage furrow
GO:0032925 IEA regulation of activin receptor signaling pathway
GO:0034968 IDA histone lysine methylation
GO:0035097 IPI histone methyltransferase complex
GO:0043065 IEA positive regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043280 IEA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045597 IEA positive regulation of cell differentiation
GO:0045668 IGI negative regulation of osteoblast differentiation
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045736 IMP negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786 IDA negative regulation of cell cycle
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 TAS positive regulation of transcription from RNA polymerase II promoter
GO:0046329 IDA negative regulation of JNK cascade
GO:0046621 IEA negative regulation of organ growth
GO:0047485 IPI protein N-terminus binding
GO:0048704 IEA embryonic skeletal system morphogenesis
GO:0051781 IEA positive regulation of cell division
GO:0051974 IMP negative regulation of telomerase activity
GO:0060021 IEA palate development
GO:0060135 IEA maternal process involved in female pregnancy
GO:0070412 IPI R-SMAD binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058021 men1 multiple endocrine neoplasia type 1 protein_coding Danio_rerio
ENSDARG00000089456 men1 multiple endocrine neoplasia type 1 protein_coding Danio_rerio
ENSMUSG00000024947 Men1 multiple endocrine neoplasia 1 protein_coding Mus_musculus

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