C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sortilin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134243 SORT1 9606 - 1:109309568-109397951 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000256637 SORT1-001 109309570-109397951 protein_coding
  ENST00000466471 SORT1-003 109326806-109336302 retained_intron
  ENST00000471996 SORT1-006 109369530-109397861 processed_transcript
  ENST00000482236 SORT1-007 109354485-109393357 processed_transcript
  ENST00000483508 SORT1-004 109366783-109369589 retained_intron
  ENST00000485149 SORT1-002 109313801-109316927 processed_transcript
  ENST00000493736 SORT1-008 109350947-109389899 processed_transcript
  ENST00000495777 SORT1-005 109368478-109369589 processed_transcript
  ENST00000538502 SORT1-201 109309568-109393357 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000256637ENST00000538502
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000256637 23.046±0.00 6.165±0.00 36.273±30.97 12.915±11.65 7.764±3.73 27.521±0.00 31.261±0.00 4.677±0.35 11.227±2.02 32.168±0.00 5.620±2.01 13.689±1.08 24.964±3.11
ENST00000538502 N/A N/A 7.307±0.00 3.485±0.00 N/A 1.293±0.00 N/A N/A N/A N/A N/A 2.593±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00098X CIL_00098X_0001 VISTA 1:108953074-109556228
CIL_00099A CIL_00099A_0001 VISTA 1:108974252-109576283
CIL_000734 CIL_000734_0002 CGP 1:109309568-109426427

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001503 IEA ossification
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005764 IEA lysosome
GO:0005769 IDA early endosome
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0005905 IDA coated pit
GO:0006895 IDA Golgi to endosome transport
GO:0006897 IDA endocytosis
GO:0007186 IMP G-protein coupled receptor signaling pathway
GO:0007218 IDA neuropeptide signaling pathway
GO:0007275 IEA multicellular organismal development
GO:0008333 IDA endosome to lysosome transport
GO:0008625 IDA extrinsic apoptotic signaling pathway via death domain receptors
GO:0009986 IDA cell surface
GO:0010465 IDA nerve growth factor receptor activity
GO:0010468 IMP regulation of gene expression
GO:0014902 IMP myotube differentiation
GO:0016021 IDA:IEA integral component of membrane
GO:0016023 IDA cytoplasmic membrane-bounded vesicle
GO:0016050 IDA vesicle organization
GO:0019899 IPI enzyme binding
GO:0030136 IDA clathrin-coated vesicle
GO:0030140 IEA trans-Golgi network transport vesicle
GO:0030379 IDA neurotensin receptor activity, non-G-protein coupled
GO:0032509 IDA endosome transport via multivesicular body sorting pathway
GO:0032868 IMP response to insulin
GO:0038180 IDA nerve growth factor signaling pathway
GO:0046323 IMP glucose import
GO:0048011 IMP neurotrophin TRK receptor signaling pathway
GO:0048227 IDA plasma membrane to endosome transport
GO:0048406 IPI nerve growth factor binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051005 IDA negative regulation of lipoprotein lipase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029402 sort1a sortilin 1a protein_coding Danio_rerio
ENSDARG00000056252 sort1b sortilin 1b protein_coding Danio_rerio
ENSMUSG00000068747 Sort1 sortilin 1 protein_coding Mus_musculus

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