C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: endoplasmic reticulum to nucleus signaling 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134398 ERN2 9606 - 16:23690326-23713500 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000256797 ERN2-001 23690376-23713500 protein_coding
  ENST00000457008 ERN2-002 23690326-23713226 protein_coding
  ENST00000561478 ERN2-008 23706807-23707363 retained_intron
  ENST00000562458 ERN2-006 23690638-23694760 nonsense_mediated_decay
  ENST00000562562 ERN2-003 23694854-23713222 nonsense_mediated_decay
  ENST00000566565 ERN2-007 23706220-23706854 retained_intron
  ENST00000569903 ERN2-004 23709604-23713210 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLungMuscleOvaryENST00000256797ENST00000457008ENST00000562458ENST00000569903
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Lung Muscle Ovary
ENST00000256797 0.059±0.00 N/A N/A 1.253±0.00 N/A N/A N/A 0.305±0.00 N/A 2.921±1.82
ENST00000457008 0.093±0.00 0.281±0.00 0.324±0.00 1.784±0.00 1.800±0.45 N/A 0.476±0.00 0.721±0.00 0.183±0.00 0.894±0.22
ENST00000562458 N/A N/A N/A N/A N/A N/A N/A 0.301±0.00 0.264±0.00 N/A
ENST00000569903 N/A N/A N/A N/A 6.668±0.00 0.224±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006D0 CIL_0006D0_0001 CGP 16:23641392-23690367
CIL_0003VD CIL_0003VD_0002 CGP 16:23677656-23713500
CIL_0006CZ CIL_0006CZ_0001 CGP 16:23690326-23758951

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0004519 IDA endonuclease activity
GO:0004540 IEA ribonuclease activity
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005783 IEA endoplasmic reticulum
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006397 IEA mRNA processing
GO:0006468 IDA:IEA protein phosphorylation
GO:0007050 IEA cell cycle arrest
GO:0016021 IEA integral component of membrane
GO:0016075 IDA rRNA catabolic process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030263 IMP apoptotic chromosome condensation
GO:0034976 IEA response to endoplasmic reticulum stress
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0070059 IEA intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090305 IDA nucleic acid phosphodiester bond hydrolysis
GO:0090501 IEA RNA phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058475 ern2 endoplasmic reticulum to nucleus signaling 2 protein_coding Danio_rerio
ENSMUSG00000030866 Ern2 endoplasmic reticulum (ER) to nucleus signalling 2 protein_coding Mus_musculus

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