C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adenomatous polyposis coli
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134982 APC 9606 + 5:112707498-112846239 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000257430 APC-001 112737888-112846239 protein_coding
  ENST00000502371 APC-007 112821896-112839871 nonsense_mediated_decay
  ENST00000504915 APC-011 112821949-112837722 protein_coding
  ENST00000505084 APC-006 112827213-112829954 retained_intron
  ENST00000505350 APC-012 112707521-112766383 nonsense_mediated_decay
  ENST00000507379 APC-002 112707522-112839054 protein_coding
  ENST00000508376 APC-004 112737895-112846056 protein_coding
  ENST00000508624 APC-003 112737885-112842755 nonsense_mediated_decay
  ENST00000509732 APC-008 112707498-112767322 protein_coding
  ENST00000512211 APC-005 112738332-112839508 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000257430ENST00000508376ENST00000508624ENST00000512211
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000257430 N/A 2.241±0.00 N/A 14.871±7.58 1.419±0.00 4.594±0.00 N/A 2.026±0.00 2.027±0.00 1.832±0.00 N/A 1.617±0.61 1.431±0.00 2.821±0.00
ENST00000508376 3.273±0.00 2.391±0.00 1.890±0.00 9.974±0.00 N/A 2.496±0.00 3.758±0.00 N/A N/A N/A N/A N/A N/A 4.499±0.00
ENST00000508624 N/A N/A N/A N/A 1.598±0.00 N/A N/A 1.370±0.00 1.825±0.00 N/A 1.336±0.00 0.863±0.00 N/A N/A
ENST00000512211 N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.807±0.00 N/A 1.933±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005KL CIL_0005KL_0002 CGP 5:112142441-112846239

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000281 IMP mitotic cytokinesis
GO:0000776 IDA kinetochore
GO:0001822 IEA kidney development
GO:0001942 IEA hair follicle development
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005881 IEA cytoplasmic microtubule
GO:0005886 IDA plasma membrane
GO:0005913 IDA cell-cell adherens junction
GO:0005923 IDA tight junction
GO:0006461 IDA protein complex assembly
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0006974 IEA:IDA cellular response to DNA damage stimulus
GO:0007026 IDA negative regulation of microtubule depolymerization
GO:0007050 IEA:IDA cell cycle arrest
GO:0007091 IEA metaphase/anaphase transition of mitotic cell cycle
GO:0007094 IMP mitotic spindle assembly checkpoint
GO:0007155 NAS cell adhesion
GO:0007389 IEA pattern specification process
GO:0007409 IEA axonogenesis
GO:0008013 IPI:IEA beta-catenin binding
GO:0008017 IDA:IEA microtubule binding
GO:0008285 IDA negative regulation of cell proliferation
GO:0009798 IEA axis specification
GO:0009952 IEA anterior/posterior pattern specification
GO:0009953 IEA dorsal/ventral pattern formation
GO:0009954 IEA proximal/distal pattern formation
GO:0016055 IEA Wnt signaling pathway
GO:0016328 IDA lateral plasma membrane
GO:0016477 IMP cell migration
GO:0019827 IEA stem cell maintenance
GO:0019887 IDA protein kinase regulator activity
GO:0019901 IPI protein kinase binding
GO:0030027 IDA lamellipodium
GO:0030178 IEA negative regulation of Wnt signaling pathway
GO:0030334 IEA regulation of cell migration
GO:0030335 IMP positive regulation of cell migration
GO:0030424 IEA axon
GO:0030426 IEA growth cone
GO:0030856 IEA regulation of epithelial cell differentiation
GO:0030858 IEA positive regulation of epithelial cell differentiation
GO:0030877 IDA beta-catenin destruction complex
GO:0031116 IEA positive regulation of microtubule polymerization
GO:0031122 IEA cytoplasmic microtubule organization
GO:0031253 IEA cell projection membrane
GO:0031274 IMP positive regulation of pseudopodium assembly
GO:0032587 IDA ruffle membrane
GO:0032886 IMP regulation of microtubule-based process
GO:0033077 IEA T cell differentiation in thymus
GO:0035019 IEA somatic stem cell maintenance
GO:0035371 IEA microtubule plus-end
GO:0042483 IEA negative regulation of odontogenesis
GO:0042995 IEA cell projection
GO:0043065 IMP positive regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043409 IEA negative regulation of MAPK cascade
GO:0043588 IEA skin development
GO:0044295 IEA axonal growth cone
GO:0044336 IEA canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044337 IEA canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045295 IPI gamma-catenin binding
GO:0045595 IEA regulation of cell differentiation
GO:0045597 IEA positive regulation of cell differentiation
GO:0045667 IEA regulation of osteoblast differentiation
GO:0045670 IEA regulation of osteoclast differentiation
GO:0045732 IGI positive regulation of protein catabolic process
GO:0045736 IDA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045785 IEA positive regulation of cell adhesion
GO:0046716 IEA muscle cell cellular homeostasis
GO:0048538 IEA thymus development
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0051010 IDA microtubule plus-end binding
GO:0051171 IEA regulation of nitrogen compound metabolic process
GO:0051276 IEA chromosome organization
GO:0051726 IEA regulation of cell cycle
GO:0051781 IEA positive regulation of cell division
GO:0051988 NAS regulation of attachment of spindle microtubules to kinetochore
GO:0060041 IEA retina development in camera-type eye
GO:0060070 NAS canonical Wnt signaling pathway
GO:0060770 IEA negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0070830 NAS tight junction assembly
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058868 apc adenomatosis polyposis coli protein_coding Danio_rerio
ENSMUSG00000005871 Apc adenomatosis polyposis coli protein_coding Mus_musculus

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