C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136238 RAC1 9606 + 7:6374523-6403977 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000348035 RAC1-001 6374523-6403977 protein_coding
  ENST00000356142 RAC1-002 6374539-6402520 protein_coding
  ENST00000473564 RAC1-005 6399823-6402365 retained_intron
  ENST00000488373 RAC1-004 6374563-6402481 processed_transcript
  ENST00000495499 RAC1-006 6401618-6402520 retained_intron
  ENST00000497741 RAC1-003 6391458-6402502 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000348035ENST00000356142ENST00000473564ENST00000497741
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000348035 94.757±0.00 95.205±0.00 5.957±0.00 72.922±62.64 25.331±17.24 50.029±39.07 26.436±25.54 38.460±33.87 19.889±14.03 56.692±49.06 48.410±45.26 79.439±42.98 144.885±16.25 56.458±15.40
ENST00000356142 N/A N/A 17.819±0.00 13.405±0.00 20.633±0.00 32.280±0.00 6.325±0.00 9.017±0.00 13.974±0.00 23.588±0.00 36.274±0.00 32.497±0.00 N/A N/A
ENST00000473564 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 152.975±0.00 84.249±0.00 36.201±0.00
ENST00000497741 N/A N/A 15.508±0.00 39.442±0.00 19.207±0.00 19.329±0.00 8.152±0.00 17.962±0.00 22.096±0.00 17.681±0.00 14.516±0.00 13.432±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 IEA Golgi membrane
GO:0001891 IEA phagocytic cup
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0002093 IEA auditory receptor cell morphogenesis
GO:0002551 IEA mast cell chemotaxis
GO:0003382 IEA epithelial cell morphogenesis
GO:0003924 TAS GTPase activity
GO:0005515 IPI protein binding
GO:0005525 IDA:IEA GTP binding
GO:0005622 IEA intracellular
GO:0005737 IDA cytoplasm
GO:0005802 IDA trans-Golgi network
GO:0005829 ISS cytosol
GO:0005884 IDA actin filament
GO:0005886 TAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0006184 IEA GTP catabolic process
GO:0006897 IEA endocytosis
GO:0006911 IEA phagocytosis, engulfment
GO:0006928 TAS cellular component movement
GO:0006935 IEA chemotaxis
GO:0006954 TAS inflammatory response
GO:0006972 IEA hyperosmotic response
GO:0007010 IEA cytoskeleton organization
GO:0007015 IEA actin filament organization
GO:0007155 TAS cell adhesion
GO:0007160 NAS cell-matrix adhesion
GO:0007165 IEA signal transduction
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008283 IEA cell proliferation
GO:0009611 TAS response to wounding
GO:0009653 TAS anatomical structure morphogenesis
GO:0010310 TAS regulation of hydrogen peroxide metabolic process
GO:0010592 IDA positive regulation of lamellipodium assembly
GO:0010811 IGI positive regulation of cell-substrate adhesion
GO:0015031 IEA protein transport
GO:0016020 ISS:IEA membrane
GO:0016023 IEA cytoplasmic membrane-bounded vesicle
GO:0016032 TAS viral process
GO:0016358 IEA dendrite development
GO:0016477 IEA cell migration
GO:0017137 IEA Rab GTPase binding
GO:0019897 IEA extrinsic component of plasma membrane
GO:0019899 IPI enzyme binding
GO:0019901 IEA protein kinase binding
GO:0021799 IEA cerebral cortex radially oriented cell migration
GO:0021831 IEA embryonic olfactory bulb interneuron precursor migration
GO:0030027 IDA lamellipodium
GO:0030032 IMP lamellipodium assembly
GO:0030036 IGI actin cytoskeleton organization
GO:0030041 TAS actin filament polymerization
GO:0030168 TAS platelet activation
GO:0030334 IMP regulation of cell migration
GO:0030742 IEA GTP-dependent protein binding
GO:0030838 IEA positive regulation of actin filament polymerization
GO:0031295 TAS T cell costimulation
GO:0031410 IEA cytoplasmic vesicle
GO:0031529 IDA ruffle organization
GO:0031996 IPI thioesterase binding
GO:0032587 IEA ruffle membrane
GO:0032707 IDA negative regulation of interleukin-23 production
GO:0034446 IMP substrate adhesion-dependent cell spreading
GO:0035025 TAS positive regulation of Rho protein signal transduction
GO:0035556 TAS intracellular signal transduction
GO:0036464 IDA cytoplasmic ribonucleoprotein granule
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042995 IEA cell projection
GO:0043065 TAS positive regulation of apoptotic process
GO:0043552 IEA positive regulation of phosphatidylinositol 3-kinase activity
GO:0043652 IEA engulfment of apoptotic cell
GO:0045087 TAS innate immune response
GO:0045216 IEA cell-cell junction organization
GO:0045453 IEA bone resorption
GO:0045740 IEA positive regulation of DNA replication
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048261 TAS negative regulation of receptor-mediated endocytosis
GO:0048532 IEA anatomical structure arrangement
GO:0048813 IEA dendrite morphogenesis
GO:0048870 IDA cell motility
GO:0050690 TAS regulation of defense response to virus by virus
GO:0051022 ISS Rho GDP-dissociation inhibitor binding
GO:0051496 IDA positive regulation of stress fiber assembly
GO:0051668 IMP localization within membrane
GO:0051894 IDA positive regulation of focal adhesion assembly
GO:0060071 IEA Wnt signaling pathway, planar cell polarity pathway
GO:0060263 IDA regulation of respiratory burst
GO:0070062 IDA extracellular vesicular exosome
GO:0071526 ISS semaphorin-plexin signaling pathway
GO:0071542 IEA dopaminergic neuron differentiation
GO:0072659 IEA protein localization to plasma membrane
GO:0090023 IMP positive regulation of neutrophil chemotaxis
GO:0090103 IEA cochlea morphogenesis
GO:0097178 IEA ruffle assembly
GO:0097190 TAS apoptotic signaling pathway
GO:1900026 IDA positive regulation of substrate adhesion-dependent cell spreading

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013203 RAC1 (1 of 8) ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) protein_coding Danio_rerio
ENSDARG00000054649 rac1l ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) like protein_coding Danio_rerio
ENSDARG00000074849 rac1a ras-related C3 botulinum toxin substrate 1a (rho family, small GTP binding protein Rac1) protein_coding Danio_rerio
ENSDARG00000087861 rac1b ras-related C3 botulinum toxin substrate 1b (rho family, small GTP binding protein Rac1) protein_coding Danio_rerio
ENSDARG00000087954 rac1b ras-related C3 botulinum toxin substrate 1b (rho family, small GTP binding protein Rac1) protein_coding Danio_rerio
ENSDARG00000094613 RAC1 (6 of 8) ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) protein_coding Danio_rerio
ENSDARG00000096549 RAC1 (7 of 8) ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) protein_coding Danio_rerio
ENSDARG00000096666 RAC1 (8 of 8) ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) protein_coding Danio_rerio
ENSMUSG00000001847 Rac1 RAS-related C3 botulinum substrate 1 protein_coding Mus_musculus

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