C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: BLK proto-oncogene, Src family tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136573 BLK 9606 + 8:11494001-11564604 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000259089 BLK-001 11494001-11564604 protein_coding
  ENST00000525389 BLK-003 11494169-11509891 processed_transcript
  ENST00000526097 BLK-005 11560333-11564599 retained_intron
  ENST00000526778 BLK-007 11549994-11556788 retained_intron
  ENST00000529894 BLK-004 11494390-11564528 protein_coding
  ENST00000533828 BLK-006 11545731-11549103 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonKidneyLiverLungOvaryPlacentaTestisENST00000259089ENST00000525389ENST00000526097ENST00000526778ENST00000529894ENST00000533828
Transcript ID Adipose Adrenal Brain Breast Colon Kidney Liver Lung Ovary Placenta Testis
ENST00000259089 0.031±0.00 19.083±0.00 N/A 0.096±0.00 0.497±0.00 N/A 0.180±0.06 0.252±0.00 0.159±0.07 N/A 0.082±0.00
ENST00000525389 N/A N/A N/A 0.040±0.00 N/A N/A N/A 0.659±0.00 N/A N/A N/A
ENST00000526097 0.173±0.00 22.128±0.00 N/A 0.080±0.01 0.025±0.00 0.584±0.00 N/A 0.083±0.00 0.117±0.04 N/A 0.065±0.03
ENST00000526778 0.149±0.00 N/A 0.014±0.00 N/A N/A N/A N/A 0.367±0.00 N/A 0.195±0.16 0.077±0.00
ENST00000529894 N/A 29.860±0.00 0.023±0.00 0.118±0.00 N/A N/A 0.084±0.00 N/A 0.143±0.01 0.198±0.11 0.091±0.00
ENST00000533828 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.094±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008Y4 CIL_0008Y4_0001 VISTA 8:11271783-11873892
CIL_000919 CIL_000919_0001 VISTA 8:11446673-12047186

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004713 IEA:TAS protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005886 IEA plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0032024 IMP positive regulation of insulin secretion
GO:0035556 TAS intracellular signal transduction
GO:0050853 IDA B cell receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007783 blk B lymphoid tyrosine kinase protein_coding Danio_rerio
ENSMUSG00000014453 Blk B lymphoid kinase protein_coding Mus_musculus

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