C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ectonucleotide pyrophosphatase/phosphodiesterase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136960 ENPP2 9606 - 8:119557086-119673453 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000075322 ENPP2-002 119557521-119638839 protein_coding
  ENST00000259486 ENPP2-003 119557086-119638830 protein_coding
  ENST00000427067 ENPP2-001 119557086-119673453 protein_coding
  ENST00000518109 ENPP2-009 119572620-119578485 processed_transcript
  ENST00000518958 ENPP2-007 119616269-119638824 nonsense_mediated_decay
  ENST00000520066 ENPP2-008 119616253-119638814 protein_coding
  ENST00000522167 ENPP2-005 119557409-119593008 protein_coding
  ENST00000522826 ENPP2-004 119557521-119638780 protein_coding
  ENST00000523861 ENPP2-006 119557087-119581107 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000075322ENST00000259486ENST00000427067ENST00000518109ENST00000520066ENST00000522167ENST00000522826
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000075322 51.897±0.00 7.404±0.00 2.498±0.00 28.611±0.00 15.028±0.93 14.268±9.46 0.537±0.26 N/A 2.035±1.44 8.389±0.97 1.590±0.99 2.983±1.81 28.040±11.99 5.993±4.35
ENST00000259486 14.793±0.00 2.433±0.00 N/A N/A 7.047±0.00 7.374±0.00 0.457±0.00 N/A 1.010±0.00 2.811±0.00 N/A 1.421±1.13 14.019±3.64 N/A
ENST00000427067 16.386±0.00 5.685±0.00 N/A 38.180±17.11 7.145±4.65 4.983±0.00 0.796±0.00 N/A 0.370±0.00 N/A N/A 0.746±0.50 14.462±5.80 4.640±0.00
ENST00000518109 0.276±0.00 0.400±0.00 N/A 1.587±0.30 0.543±0.00 0.122±0.00 0.061±0.00 0.075±0.00 0.874±0.00 0.270±0.19 N/A 0.120±0.03 0.368±0.00 0.260±0.21
ENST00000520066 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.555±0.00 N/A N/A N/A
ENST00000522167 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.309±2.58 36.307±20.41 5.294±0.00
ENST00000522826 N/A N/A N/A 10.830±5.08 N/A N/A N/A N/A N/A N/A N/A 0.244±0.00 N/A 3.927±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005I1 CIL_0005I1_0001 CGP 8:119416306-119673453
CIL_0002T6 CIL_0002T6_0001 CGP 8:119557086-119832863

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003676 IEA nucleic acid binding
GO:0003824 IEA catalytic activity
GO:0004528 TAS phosphodiesterase I activity
GO:0004551 TAS nucleotide diphosphatase activity
GO:0004622 IDA lysophospholipase activity
GO:0005044 IEA scavenger receptor activity
GO:0005509 ISS calcium ion binding
GO:0005615 ISS extracellular space
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006796 TAS phosphate-containing compound metabolic process
GO:0006898 IEA receptor-mediated endocytosis
GO:0006928 TAS cellular component movement
GO:0006935 NAS chemotaxis
GO:0006955 IEA immune response
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0008134 TAS transcription factor binding
GO:0008152 IEA metabolic process
GO:0008270 ISS zinc ion binding
GO:0009395 IDA phospholipid catabolic process
GO:0016787 TAS:IEA hydrolase activity
GO:0030247 IEA polysaccharide binding
GO:0030334 IDA regulation of cell migration
GO:0034638 IDA phosphatidylcholine catabolic process
GO:0046872 IEA metal ion binding
GO:0047391 IEA alkylglycerophosphoethanolamine phosphodiesterase activity
GO:0090305 TAS nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011257 enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 protein_coding Danio_rerio
ENSDARG00000075384 enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 protein_coding Danio_rerio
ENSMUSG00000022425 Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 protein_coding Mus_musculus

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