C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sortilin-related receptor, L(DLR class) A repeats containing
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000137642 SORL1 9606 + 11:121452203-121633693 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000260197 SORL1-001 121452203-121633693 protein_coding
  ENST00000524633 SORL1-011 121614286-121622269 retained_intron
  ENST00000524873 SORL1-008 121557015-121558773 retained_intron
  ENST00000525532 SORL1-003 121566725-121629684 protein_coding
  ENST00000527649 SORL1-012 121626201-121629693 retained_intron
  ENST00000527934 SORL1-006 121590419-121629684 protein_coding
  ENST00000528339 SORL1-009 121608200-121621240 retained_intron
  ENST00000529445 SORL1-007 121555042-121558837 retained_intron
  ENST00000530365 SORL1-013 121628836-121632240 retained_intron
  ENST00000532451 SORL1-002 121452380-121547024 processed_transcript
  ENST00000532694 SORL1-004 121576760-121629691 protein_coding
  ENST00000534286 SORL1-005 121576838-121629678 protein_coding
  ENST00000534754 SORL1-010 121611252-121621234 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000260197ENST00000525532ENST00000532451
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000260197 0.444±0.00 1.537±0.00 4.365±0.00 15.993±4.64 1.636±0.96 2.591±2.19 0.381±0.13 13.744±9.24 4.862±2.70 4.383±0.96 0.016±0.00 3.119±2.18 0.555±0.05 1.602±0.80
ENST00000525532 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.318±0.00 N/A N/A N/A
ENST00000532451 N/A N/A N/A N/A N/A N/A 0.697±0.00 N/A N/A N/A 0.185±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000042 IDA protein targeting to Golgi
GO:0001540 IPI beta-amyloid binding
GO:0004888 TAS transmembrane signaling receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005615 IDA extracellular space
GO:0005641 IDA nuclear envelope lumen
GO:0005768 IDA endosome
GO:0005769 IMP early endosome
GO:0005771 IEA multivesicular body
GO:0005783 IDA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005802 IDA trans-Golgi network
GO:0005887 TAS integral component of plasma membrane
GO:0006605 IMP protein targeting
GO:0006622 IDA protein targeting to lysosome
GO:0006869 IEA lipid transport
GO:0006892 IDA post-Golgi vesicle-mediated transport
GO:0006898 TAS receptor-mediated endocytosis
GO:0007165 TAS signal transduction
GO:0008203 IEA cholesterol metabolic process
GO:0008219 IEA cell death
GO:0008283 IEA cell proliferation
GO:0014910 IDA regulation of smooth muscle cell migration
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016477 IEA cell migration
GO:0030169 IPI low-density lipoprotein particle binding
GO:0030306 IPI ADP-ribosylation factor binding
GO:0031985 IDA Golgi cisterna
GO:0032091 IDA negative regulation of protein binding
GO:0032460 IMP negative regulation of protein oligomerization
GO:0034362 IEA low-density lipoprotein particle
GO:0043025 IEA neuronal cell body
GO:0043407 ISS negative regulation of MAP kinase activity
GO:0045053 IDA protein retention in Golgi apparatus
GO:0045732 IDA positive regulation of protein catabolic process
GO:0050768 ISS negative regulation of neurogenesis
GO:0051604 IDA protein maturation
GO:0055037 IMP recycling endosome
GO:0070062 IDA extracellular vesicular exosome
GO:0070863 IMP positive regulation of protein exit from endoplasmic reticulum
GO:1901215 ISS negative regulation of neuron death
GO:1902430 IDA negative regulation of beta-amyloid formation
GO:1902771 ISS positive regulation of choline O-acetyltransferase activity
GO:1902948 ISS negative regulation of tau-protein kinase activity
GO:1902953 IMP positive regulation of ER to Golgi vesicle-mediated transport
GO:1902955 IMP positive regulation of early endosome to recycling endosome transport
GO:1902960 IDA negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 IMP negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966 IMP positive regulation of protein localization to early endosome
GO:1902997 ISS negative regulation of neurofibrillary tangle assembly
GO:2001137 IMP positive regulation of endocytic recycling

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013892 sorl1 sortilin-related receptor, L(DLR class) A repeats containing protein_coding Danio_rerio
ENSMUSG00000049313 Sorl1 sortilin-related receptor, LDLR class A repeats-containing protein_coding Mus_musculus

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