C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SMAD family member 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000137834 SMAD6 9606 + 15:66702228-66782848 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000288840 SMAD6-001 66702228-66782848 protein_coding
  ENST00000557916 SMAD6-002 66703259-66781313 nonsense_mediated_decay
  ENST00000558937 SMAD6-004 66711697-66717537 protein_coding
  ENST00000559931 SMAD6-003 66711676-66781313 nonsense_mediated_decay
  ENST00000612349 SMAD6-006 66703077-66708274 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000288840ENST00000557916ENST00000559931ENST00000612349
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000288840 2.504±0.00 1.859±0.00 0.831±0.00 0.770±0.21 1.706±1.54 1.216±0.50 2.623±0.00 2.424±0.98 1.180±0.51 2.899±0.54 1.219±0.00 2.735±1.51 7.420±3.23 1.903±1.07
ENST00000557916 N/A N/A N/A N/A N/A N/A N/A 3.859±2.30 4.659±0.00 5.291±0.00 0.366±0.00 N/A N/A N/A
ENST00000559931 N/A 3.157±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.065±0.00 N/A 5.286±0.00
ENST00000612349 1.012±0.00 0.746±0.00 0.599±0.00 0.358±0.22 0.792±0.32 1.014±0.14 0.530±0.27 0.715±0.36 0.586±0.08 1.432±0.00 N/A 2.274±1.17 1.392±0.41 0.510±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008Q7 CIL_0008Q7_0001 VISTA 15:66378983-66980203
CIL_0008R9 CIL_0008R9_0001 VISTA 15:66606636-67207796
CIL_000471 CIL_000471_0002 CGP 15:66702228-67195195

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001657 IEA ureteric bud development
GO:0003682 IDA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005667 IEA transcription factor complex
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006955 IMP immune response
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007352 IMP zygotic specification of dorsal/ventral axis
GO:0008285 IMP negative regulation of cell proliferation
GO:0010991 IDA negative regulation of SMAD protein complex assembly
GO:0030509 IDA BMP signaling pathway
GO:0030512 IMP negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 IDA negative regulation of BMP signaling pathway
GO:0030617 IMP transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0031589 IMP cell-substrate adhesion
GO:0031625 IPI ubiquitin protein ligase binding
GO:0034616 IEP response to laminar fluid shear stress
GO:0034713 IDA type I transforming growth factor beta receptor binding
GO:0035556 IMP intracellular signal transduction
GO:0043066 IMP negative regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043627 IEA response to estrogen
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045444 IDA fat cell differentiation
GO:0046872 IEA metal ion binding
GO:0060394 IMP negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0070410 IPI co-SMAD binding
GO:0070411 IPI I-SMAD binding
GO:0070412 IPI R-SMAD binding
GO:0070698 IDA type I activin receptor binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031763 smad6b SMAD family member 6b protein_coding Danio_rerio
ENSMUSG00000036867 Smad6 SMAD family member 6 protein_coding Mus_musculus

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