C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138029 HADHB 9606 + 2:26243170-26290468 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000317799 HADHB-001 26244895-26290468 protein_coding
  ENST00000405867 HADHB-002 26244926-26290412 protein_coding
  ENST00000412805 HADHB-005 26245130-26269997 protein_coding
  ENST00000425035 HADHB-004 26244979-26278698 protein_coding
  ENST00000448743 HADHB-007 26243170-26278620 protein_coding
  ENST00000479347 HADHB-006 26244920-26254956 retained_intron
  ENST00000494615 HADHB-003 26260538-26290464 processed_transcript
  ENST00000537713 HADHB-201 26244748-26290464 protein_coding
  ENST00000545822 HADHB-202 26261021-26290464 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000317799ENST00000425035ENST00000448743ENST00000537713ENST00000545822
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000317799 32.018±0.00 25.767±0.00 13.618±0.00 17.214±0.66 16.147±8.62 23.060±6.91 184.069±139.68 37.948±9.70 21.838±4.59 19.225±4.33 109.652±35.73 24.492±12.58 26.636±2.99 15.944±0.86
ENST00000425035 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 18.120±0.00 23.532±0.00
ENST00000448743 N/A N/A N/A N/A 8.688±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000537713 N/A N/A N/A N/A 1.447±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000545822 27.241±0.00 13.266±0.00 N/A 22.381±0.00 21.453±0.00 20.888±0.00 51.735±0.00 30.372±0.00 38.114±0.00 8.899±0.00 27.535±0.00 21.484±0.00 16.113±4.17 24.629±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007DH CIL_0007DH_0001 CGP 2:26173091-26244726
CIL_0007DK CIL_0007DK_0001 CGP 2:26190635-26290468
CIL_0007DJ CIL_0007DJ_0001 CGP 2:26243170-26346817

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000062 IEA fatty-acyl-CoA binding
GO:0003824 IEA catalytic activity
GO:0003857 TAS 3-hydroxyacyl-CoA dehydrogenase activity
GO:0003988 IEA acetyl-CoA C-acyltransferase activity
GO:0004300 IEA enoyl-CoA hydratase activity
GO:0005515 IPI protein binding
GO:0005739 NAS mitochondrion
GO:0005740 TAS mitochondrial envelope
GO:0005741 IDA mitochondrial outer membrane
GO:0005743 IDA mitochondrial inner membrane
GO:0005783 IDA endoplasmic reticulum
GO:0006635 IEA fatty acid beta-oxidation
GO:0006644 TAS phospholipid metabolic process
GO:0008152 IEA metabolic process
GO:0016507 IEA mitochondrial fatty acid beta-oxidation multienzyme complex
GO:0016508 IEA long-chain-enoyl-CoA hydratase activity
GO:0016509 IEA long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0016747 IEA transferase activity, transferring acyl groups other than amino-acyl groups
GO:0032403 IEA protein complex binding
GO:0035965 TAS cardiolipin acyl-chain remodeling
GO:0042645 IDA mitochondrial nucleoid
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0046474 TAS glycerophospholipid biosynthetic process
GO:0051287 IEA NAD binding
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000057147 hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta sub protein_coding Danio_rerio
ENSMUSG00000059447 Hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta sub protein_coding Mus_musculus

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