C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein phosphatase, Mg2+/Mn2+ dependent, 1B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138032 PPM1B 9606 + 2:44167969-44244384 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000282412 PPM1B-001 44168877-44231472 protein_coding
  ENST00000345249 PPM1B-003 44168910-44231472 protein_coding
  ENST00000378540 PPM1B-007 44168877-44244384 processed_transcript
  ENST00000378551 PPM1B-002 44168877-44234646 protein_coding
  ENST00000409432 PPM1B-004 44168877-44231471 protein_coding
  ENST00000409473 PPM1B-011 44201186-44218537 protein_coding
  ENST00000409486 PPM1B-006 44168877-44209432 retained_intron
  ENST00000419807 PPM1B-005 44167969-44218537 protein_coding
  ENST00000459690 PPM1B-010 44201946-44232721 processed_transcript
  ENST00000487286 PPM1B-009 44202017-44244383 processed_transcript
  ENST00000488866 PPM1B-012 44217822-44219203 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000282412ENST00000345249ENST00000378540ENST00000378551ENST00000409432ENST00000409473ENST00000409486ENST00000419807
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000282412 9.328±0.00 8.818±0.00 2.380±0.00 11.908±5.67 3.697±1.03 3.946±1.69 4.678±3.30 4.454±2.50 2.095±0.00 5.322±0.00 9.208±4.78 6.708±1.44 4.199±0.67 6.270±0.63
ENST00000345249 N/A N/A N/A N/A 6.686±0.00 N/A N/A N/A 6.148±0.00 N/A N/A 2.934±0.00 N/A 9.385±0.00
ENST00000378540 N/A N/A 1.320±0.00 N/A N/A 4.076±0.00 1.930±0.00 6.433±0.00 4.105±0.00 4.185±1.21 N/A 5.881±0.00 N/A 9.398±0.00
ENST00000378551 4.948±0.00 4.063±0.00 0.916±0.00 3.286±0.00 5.733±1.99 4.293±1.29 1.243±0.48 6.359±2.57 4.430±2.17 1.949±0.09 4.036±2.58 4.395±1.56 2.377±0.20 4.101±1.77
ENST00000409432 N/A N/A N/A N/A N/A 1.207±0.00 N/A N/A 1.508±0.00 1.710±0.00 N/A N/A N/A N/A
ENST00000409473 N/A N/A N/A 21.516±0.00 N/A N/A 8.883±0.00 N/A N/A N/A 13.479±0.00 N/A N/A N/A
ENST00000409486 N/A N/A 2.834±0.00 5.322±0.00 6.682±0.00 2.273±0.00 1.798±0.00 N/A 4.704±0.00 6.498±0.00 9.590±0.00 7.576±0.00 N/A N/A
ENST00000419807 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.822±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001XM CIL_0001XM_0001 CGP 2:43886508-44244384
CIL_0004BC CIL_0004BC_0001 CGP 2:44167969-44321494

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0003824 IEA catalytic activity
GO:0004721 IEA phosphoprotein phosphatase activity
GO:0004722 IEA:IDA protein serine/threonine phosphatase activity
GO:0005515 IPI protein binding
GO:0005829 ISS cytosol
GO:0006470 IEA:IMP protein dephosphorylation
GO:0006499 ISS N-terminal protein myristoylation
GO:0016020 ISS membrane
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0030145 IEA manganese ion binding
GO:0032688 IMP negative regulation of interferon-beta production
GO:0035970 IDA peptidyl-threonine dephosphorylation
GO:0042347 IMP negative regulation of NF-kappaB import into nucleus
GO:0043124 IMP negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050687 IMP negative regulation of defense response to virus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011496 ppm1bb protein phosphatase, Mg2+/Mn2+ dependent, 1Bb protein_coding Danio_rerio
ENSMUSG00000061130 Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform protein_coding Mus_musculus

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