C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pancreatic and duodenal homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000139515 PDX1 9606 + 13:27920020-27926231 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000381033 PDX1-001 27920020-27926231 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonLiverOvaryTestisENST00000381033
Transcript ID Adipose Brain Breast Colon Liver Ovary Testis
ENST00000381033 0.049±0.00 0.023±0.00 0.392±0.00 0.010±0.00 0.071±0.00 2.345±1.60 0.139±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008CO CIL_0008CO_0001 VISTA 13:27444442-28045997
CIL_0007MT CIL_0007MT_0001 UCNEbase 13:27505095-28294517
CIL_00082E CIL_00082E_0001 VISTA 13:27521824-28123399
CIL_0003F7 CIL_0003F7_0001 CGP 13:27792643-27926231

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046 IEA core promoter sequence-specific DNA binding
GO:0001889 IEA liver development
GO:0003309 ISS type B pancreatic cell differentiation
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 TAS sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0006006 IEA glucose metabolic process
GO:0006091 TAS generation of precursor metabolites and energy
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007224 IEA smoothened signaling pathway
GO:0007263 IDA nitric oxide mediated signal transduction
GO:0007417 IEA central nervous system development
GO:0008134 IEA transcription factor binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0009611 IEA response to wounding
GO:0009749 IEA response to glucose
GO:0009887 TAS organ morphogenesis
GO:0010040 IEA response to iron(II) ion
GO:0010157 IEA response to chlorate
GO:0010260 IEA organ senescence
GO:0010942 IEA positive regulation of cell death
GO:0014070 IEA response to organic cyclic compound
GO:0016331 IEA morphogenesis of embryonic epithelium
GO:0030073 IDA insulin secretion
GO:0030154 IEA cell differentiation
GO:0031016 IEA pancreas development
GO:0031017 IEA exocrine pancreas development
GO:0031018 TAS endocrine pancreas development
GO:0031100 IEA organ regeneration
GO:0031667 IEA response to nutrient levels
GO:0032024 IEA positive regulation of insulin secretion
GO:0032403 IEA protein complex binding
GO:0033273 IEA response to vitamin
GO:0033993 IEA response to lipid
GO:0034097 IEA response to cytokine
GO:0035094 IEA response to nicotine
GO:0042127 IEA regulation of cell proliferation
GO:0042493 IEA response to drug
GO:0042593 IEA glucose homeostasis
GO:0043201 IEA response to leucine
GO:0043279 IEA response to alkaloid
GO:0043388 IEA positive regulation of DNA binding
GO:0043565 IEA sequence-specific DNA binding
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0048565 IEA digestive tract development
GO:0048863 IEA stem cell differentiation
GO:0051384 IEA response to glucocorticoid
GO:0051594 ISS detection of glucose
GO:0060290 IEA transdifferentiation
GO:0070542 IEA response to fatty acid
GO:1902236 IEA negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:2000675 IEA negative regulation of type B pancreatic cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002779 pdx1 pancreatic and duodenal homeobox 1 protein_coding Danio_rerio
ENSMUSG00000029644 Pdx1 pancreatic and duodenal homeobox 1 protein_coding Mus_musculus

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