C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) subunit, beta type, 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000142507 PSMB6 9606 + 17:4796144-4798503 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000270586 PSMB6-001 4796144-4798503 protein_coding
  ENST00000571309 PSMB6-003 4796204-4798329 nonsense_mediated_decay
  ENST00000575079 PSMB6-002 4796161-4797174 retained_intron
  ENST00000575643 PSMB6-004 4797684-4798475 retained_intron
  ENST00000614486 PSMB6-201 4796144-4798502 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000270586ENST00000571309
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000270586 62.999±0.00 84.317±0.00 8.793±0.00 28.608±8.92 44.484±34.34 32.854±23.66 39.803±28.12 42.396±30.51 47.690±38.38 35.254±29.85 77.282±47.19 56.739±33.63 141.595±45.38 45.817±11.41
ENST00000571309 11.116±0.00 20.719±0.00 N/A 19.361±0.00 N/A 18.776±0.00 17.074±0.00 38.710±0.00 32.340±0.00 18.762±0.00 25.361±0.00 N/A N/A 19.814±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003CM CIL_0003CM_0001 CGP 17:4788959-4798503
CIL_0001RF CIL_0001RF_0001 CGP 17:4796144-4823434

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004175 NAS endopeptidase activity
GO:0004298 IEA threonine-type endopeptidase activity
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0005839 ISS:IEA proteasome core complex
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051603 IEA proteolysis involved in cellular protein catabolic process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002240 psmb6 proteasome (prosome, macropain) subunit, beta type, 6 protein_coding Danio_rerio
ENSMUSG00000018286 Psmb6 proteasome (prosome, macropain) subunit, beta type 6 protein_coding Mus_musculus

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