C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000145649 GZMA 9606 + 5:55102648-55110252 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000274306 GZMA-001 55102648-55110252 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000274306
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000274306 0.489±0.00 12.983±0.00 0.179±0.00 0.074±0.03 1.983±0.72 1.989±1.49 0.753±0.04 0.838±0.00 1.162±0.11 7.364±4.56 0.064±0.00 1.921±0.91 2.133±0.20 0.678±0.52

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007VR CIL_0007VR_0001 VISTA 5:54641348-55243901

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001772 TAS immunological synapse
GO:0003824 IEA catalytic activity
GO:0004252 IDA:IEA serine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005576 IEA extracellular region
GO:0005634 TAS nucleus
GO:0006508 IEA proteolysis
GO:0006915 TAS apoptotic process
GO:0006955 TAS immune response
GO:0008236 IEA serine-type peptidase activity
GO:0019835 IEA cytolysis
GO:0032078 IDA negative regulation of endodeoxyribonuclease activity
GO:0042803 IDA protein homodimerization activity
GO:0043065 IDA positive regulation of apoptotic process
GO:0043392 IDA negative regulation of DNA binding
GO:0051354 IDA negative regulation of oxidoreductase activity
GO:0051603 IDA proteolysis involved in cellular protein catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000023132 Gzma granzyme A protein_coding Mus_musculus

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