C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: metadherin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000147649 MTDH 9606 + 8:97644179-97728770 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000336273 MTDH-001 97644179-97728770 protein_coding
  ENST00000519293 MTDH-004 97691019-97724652 nonsense_mediated_decay
  ENST00000519934 MTDH-002 97644546-97725243 protein_coding
  ENST00000521933 MTDH-006 97691131-97724617 protein_coding
  ENST00000522104 MTDH-005 97706412-97719087 retained_intron
  ENST00000522313 MTDH-003 97644793-97691164 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000336273ENST00000519934ENST00000522313
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000336273 8.080±0.00 8.122±0.00 3.175±0.00 5.899±0.43 9.045±0.44 7.986±0.22 4.103±1.04 8.170±0.60 8.210±0.21 7.427±1.67 5.043±3.26 10.946±2.49 3.569±1.07 7.064±1.55
ENST00000519934 9.562±0.00 N/A 7.640±0.00 7.394±1.38 8.787±0.01 8.381±1.11 5.362±1.95 8.996±0.89 8.008±0.13 9.064±0.06 4.600±1.16 8.252±2.09 2.536±0.57 6.790±2.52
ENST00000522313 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 24.360±0.00 7.563±0.00 15.684±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001L2 CIL_0001L2_0001 CGP 8:97273474-97728770
CIL_0001KW CIL_0001KW_0001 CGP 8:97644179-97853013

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0003713 IMP transcription coactivator activity
GO:0003725 IDA double-stranded RNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005789 ISS endoplasmic reticulum membrane
GO:0005923 ISS tight junction
GO:0010508 IDA positive regulation of autophagy
GO:0016021 IEA integral component of membrane
GO:0016324 ISS apical plasma membrane
GO:0016604 IDA nuclear body
GO:0031663 IMP lipopolysaccharide-mediated signaling pathway
GO:0043066 IDA negative regulation of apoptotic process
GO:0043123 IDA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044822 IDA poly(A) RNA binding
GO:0045766 IDA positive regulation of angiogenesis
GO:0046581 ISS intercellular canaliculus
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051059 IPI NF-kappaB binding
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0070830 IEA tight junction assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004939 mtdhb metadherin b protein_coding Danio_rerio
ENSDARG00000014159 mtdha metadherin a protein_coding Danio_rerio
ENSMUSG00000022255 Mtdh metadherin protein_coding Mus_musculus

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