C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000147883 CDKN2B 9606 - 9:22002903-22009363 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000276925 CDKN2B-001 22002903-22009363 protein_coding
  ENST00000380142 CDKN2B-002 22005987-22009272 protein_coding
  ENST00000579591 CDKN2B-003 22005203-22006271 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000276925ENST00000380142ENST00000579591
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000276925 4.790±0.00 0.433±0.00 0.054±0.00 0.337±0.06 14.075±9.23 2.249±1.07 0.287±0.11 0.355±0.00 0.763±0.59 2.682±0.71 1.220±0.96 1.124±0.89 0.804±0.39 1.112±0.65
ENST00000380142 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.252±0.00 N/A
ENST00000579591 5.945±0.00 0.776±0.00 N/A 0.909±0.00 43.133±0.00 2.971±1.12 0.488±0.00 N/A 1.659±1.49 10.181±0.00 3.738±0.00 5.661±5.36 1.216±0.70 10.047±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007YE CIL_0007YE_0001 VISTA 9:21773412-22380489
CIL_0007U7 CIL_0007U7_0001 VISTA 9:21778886-22382106
CIL_0007YH CIL_0007YH_0001 VISTA 9:21779916-22382548
CIL_0007YG CIL_0007YG_0001 VISTA 9:21783894-22389830
CIL_0007U8 CIL_0007U8_0001 VISTA 9:21787553-22389799
CIL_00095D CIL_00095D_0001 VISTA 9:21788649-22389830
CIL_000945 CIL_000945_0001 VISTA 9:21789705-22397955
CIL_0008WE CIL_0008WE_0001 VISTA 9:21797850-22401302
CIL_0007YC CIL_0007YC_0001 VISTA 9:21801286-22408086
CIL_00099P CIL_00099P_0001 VISTA 9:21802665-22404754
CIL_0008P9 CIL_0008P9_0001 VISTA 9:21802671-22404650
CIL_00099O CIL_00099O_0001 VISTA 9:21806995-22409801
CIL_0008TL CIL_0008TL_0001 VISTA 9:21807568-22413901
CIL_00094Y CIL_00094Y_0001 VISTA 9:21816988-22419575
CIL_0008SY CIL_0008SY_0001 VISTA 9:21818504-22425326
CIL_0008T0 CIL_0008T0_0001 VISTA 9:21825013-22425357
CIL_00085X CIL_00085X_0001 VISTA 9:21825358-22430491
CIL_00094Z CIL_00094Z_0001 VISTA 9:21827678-22430449
CIL_0008GG CIL_0008GG_0001 VISTA 9:21841068-22443944
CIL_00074F CIL_00074F_0001 CGP 9:22002903-22455740

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000079 IDA regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 IMP G2/M transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0001889 IEA liver development
GO:0004861 IDA cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 TAS transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007050 IMP cell cycle arrest
GO:0007093 IMP mitotic cell cycle checkpoint
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007568 IEA aging
GO:0008285 IMP negative regulation of cell proliferation
GO:0010467 TAS gene expression
GO:0014070 IEA response to organic cyclic compound
GO:0019901 IPI protein kinase binding
GO:0030219 IEP megakaryocyte differentiation
GO:0030511 IMP positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030858 IEA positive regulation of epithelial cell differentiation
GO:0031668 IMP cellular response to extracellular stimulus
GO:0031670 IMP cellular response to nutrient
GO:0034097 IEA response to cytokine
GO:0042326 IDA negative regulation of phosphorylation
GO:0045944 TAS positive regulation of transcription from RNA polymerase II promoter
GO:0048536 IEA spleen development
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0071901 IDA negative regulation of protein serine/threonine kinase activity
GO:2000134 IEA negative regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037262 CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) protein_coding Danio_rerio
ENSMUSG00000073802 Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) protein_coding Mus_musculus

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