C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hematopoietically expressed homeobox
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000152804 HHEX 9606 + 10:92689951-92695646 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000282728 HHEX-001 92689951-92695646 protein_coding
  ENST00000472590 HHEX-002 92691820-92695641 protein_coding
  ENST00000492654 HHEX-003 92692032-92694788 protein_coding
  ENST00000551454 HHEX-004 92689955-92692483 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000282728ENST00000472590ENST00000492654ENST00000551454
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000282728 3.458±0.00 13.825±0.00 N/A 0.464±0.18 2.642±1.56 1.568±1.44 0.598±0.15 4.094±1.45 7.515±7.03 2.691±1.58 0.660±0.02 1.873±0.71 6.924±2.16 3.539±0.00
ENST00000472590 0.561±0.00 3.395±0.00 0.032±0.00 0.290±0.22 N/A N/A 0.181±0.00 2.009±0.00 0.695±0.00 0.671±0.00 N/A 0.543±0.22 N/A 0.456±0.00
ENST00000492654 N/A N/A N/A 0.314±0.00 N/A N/A 0.412±0.00 N/A 0.320±0.00 N/A 0.579±0.00 0.831±0.00 N/A 0.557±0.00
ENST00000551454 N/A N/A N/A N/A N/A 1.069±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007VX CIL_0007VX_0001 VISTA 10:92454239-93058232
CIL_00018T CIL_00018T_0001 CGP 10:92593286-92695646
CIL_0000ZV CIL_0000ZV_0001 CGP 10:92689951-93059493

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001570 IEA vasculogenesis
GO:0001701 IEA in utero embryonic development
GO:0001889 IEA liver development
GO:0002009 IEA morphogenesis of an epithelium
GO:0002573 IEA myeloid leukocyte differentiation
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IEA:IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006406 IDA mRNA export from nucleus
GO:0007165 IEA signal transduction
GO:0007492 IEA endoderm development
GO:0008134 IPI transcription factor binding
GO:0008190 IDA eukaryotic initiation factor 4E binding
GO:0008283 IDA cell proliferation
GO:0008301 IDA DNA binding, bending
GO:0009611 IEA response to wounding
GO:0009887 IEA organ morphogenesis
GO:0009952 ISS anterior/posterior pattern specification
GO:0010621 IC negative regulation of transcription by transcription factor localization
GO:0010944 TAS negative regulation of transcription by competitive promoter binding
GO:0016055 IEA Wnt signaling pathway
GO:0016525 ISS negative regulation of angiogenesis
GO:0016973 IMP poly(A)+ mRNA export from nucleus
GO:0017025 TAS TBP-class protein binding
GO:0022027 IEA interkinetic nuclear migration
GO:0030097 IEA hemopoiesis
GO:0030154 IC cell differentiation
GO:0030177 ISS positive regulation of Wnt signaling pathway
GO:0030183 ISS B cell differentiation
GO:0030878 IEA thyroid gland development
GO:0030900 IEA forebrain development
GO:0030948 ISS negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031016 IEA pancreas development
GO:0032993 IDA protein-DNA complex
GO:0034504 IDA protein localization to nucleus
GO:0035050 IEA embryonic heart tube development
GO:0035264 IEA multicellular organism growth
GO:0042127 IEA regulation of cell proliferation
GO:0042803 IPI protein homodimerization activity
GO:0043434 IEA response to peptide hormone
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045736 IDA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048568 IEA embryonic organ development
GO:0048729 IEA tissue morphogenesis
GO:0048853 IEA forebrain morphogenesis
GO:0060431 IEA primary lung bud formation
GO:0061009 IEA common bile duct development
GO:0061010 IEA gall bladder development
GO:0061011 IEA hepatic duct development
GO:0061017 IEA hepatoblast differentiation
GO:0070365 IEA hepatocyte differentiation
GO:0070491 IDA repressing transcription factor binding
GO:0071103 IDA DNA conformation change
GO:0071837 IEA HMG box domain binding
GO:0090009 IEA primitive streak formation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000024986 Hhex hematopoietically expressed homeobox protein_coding Mus_musculus

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