C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MER proto-oncogene, tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000153208 MERTK 9606 + 2:111898479-112029561 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000295408 MERTK-001 111898479-112029561 protein_coding
  ENST00000409780 MERTK-002 111898629-112029367 protein_coding
  ENST00000421804 MERTK-201 111898608-112029366 protein_coding
  ENST00000439966 MERTK-003 111898664-112029000 nonsense_mediated_decay
  ENST00000449344 MERTK-005 112019413-112028663 protein_coding
  ENST00000473065 MERTK-004 111997370-112003443 retained_intron
  ENST00000616902 MERTK-202 111982913-112028563 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000295408ENST00000409780ENST00000421804ENST00000439966ENST00000449344
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000295408 0.560±0.00 0.735±0.00 N/A 0.850±0.20 N/A 0.372±0.00 0.737±0.00 1.365±0.00 0.786±0.00 0.283±0.00 N/A N/A N/A 2.197±0.55
ENST00000409780 1.369±0.00 N/A N/A 0.684±0.00 1.347±0.00 N/A N/A N/A 0.634±0.00 N/A 0.555±0.00 0.809±0.00 N/A 1.149±0.00
ENST00000421804 1.049±0.00 N/A 2.960±0.00 1.422±0.00 2.705±0.00 0.872±0.36 0.574±0.00 2.369±0.02 2.709±0.00 1.277±0.22 N/A 2.003±0.51 3.705±1.28 N/A
ENST00000439966 3.236±0.00 3.743±0.00 N/A 3.637±0.00 2.362±1.30 1.629±0.34 1.418±0.00 8.458±0.00 2.820±2.04 1.604±0.09 0.320±0.06 3.675±1.82 5.008±2.13 5.910±2.36
ENST00000449344 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.650±0.00 0.646±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00047R CIL_00047R_0001 CGP 2:111766271-112029561
CIL_00038G CIL_00038G_0002 CGP 2:111898479-112119318

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001750 IEA photoreceptor outer segment
GO:0001779 IEA natural killer cell differentiation
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005615 IDA extracellular space
GO:0005737 IDA cytoplasm
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006468 TAS:IEA protein phosphorylation
GO:0006909 IMP phagocytosis
GO:0007166 TAS cell surface receptor signaling pathway
GO:0007267 TAS cell-cell signaling
GO:0007283 IEA spermatogenesis
GO:0007596 TAS blood coagulation
GO:0016021 IEA integral component of membrane
GO:0016028 IDA rhabdomere
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030168 IEA platelet activation
GO:0032940 IEA secretion by cell
GO:0034446 IEA substrate adhesion-dependent cell spreading
GO:0043277 IEA apoptotic cell clearance
GO:0043491 IEA protein kinase B signaling
GO:0050766 IDA positive regulation of phagocytosis
GO:0050900 TAS leukocyte migration
GO:0051250 IEA negative regulation of lymphocyte activation
GO:0060041 IEA retina development in camera-type eye
GO:0060068 IEA vagina development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074695 mertk c-mer proto-oncogene tyrosine kinase protein_coding Danio_rerio
ENSMUSG00000014361 Mertk c-mer proto-oncogene tyrosine kinase protein_coding Mus_musculus

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