C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin 6 receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000160712 IL6R 9606 + 1:154405193-154469450 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000344086 IL6R-003 154405223-154466877 protein_coding
  ENST00000368485 IL6R-001 154405193-154469450 protein_coding
  ENST00000476006 IL6R-002 154429343-154449979 protein_coding
  ENST00000502679 IL6R-006 154454109-154465248 retained_intron
  ENST00000507256 IL6R-005 154435010-154465314 processed_transcript
  ENST00000512471 IL6R-004 154405615-154434583 protein_coding
  ENST00000515190 IL6R-007 154434653-154454583 protein_coding
  ENST00000622330 IL6R-201 154405193-154437544 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000344086ENST00000368485
Transcript ID Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000344086 N/A 0.158±0.00 N/A N/A 0.583±0.00 N/A N/A 2.353±0.00 2.764±0.00 1.297±0.00 N/A N/A
ENST00000368485 2.943±0.00 0.240±0.00 1.519±0.71 3.027±1.05 0.465±0.00 4.636±1.10 3.994±2.95 7.936±0.00 33.845±0.00 3.341±1.89 0.943±0.57 2.146±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002384 TAS hepatic immune response
GO:0002446 IC neutrophil mediated immunity
GO:0002548 IC monocyte chemotaxis
GO:0002690 TAS positive regulation of leukocyte chemotaxis
GO:0004897 IMP ciliary neurotrophic factor receptor activity
GO:0004915 IDA interleukin-6 receptor activity
GO:0005138 IPI interleukin-6 receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005576 IDA extracellular region
GO:0005615 IDA extracellular space
GO:0005886 TAS plasma membrane
GO:0005896 IDA interleukin-6 receptor complex
GO:0006953 TAS acute-phase response
GO:0008284 IMP positive regulation of cell proliferation
GO:0010536 IDA positive regulation of activation of Janus kinase activity
GO:0016324 IDA apical plasma membrane
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0019899 IPI enzyme binding
GO:0019981 IPI interleukin-6 binding
GO:0031018 IC endocrine pancreas development
GO:0032717 IEP negative regulation of interleukin-8 production
GO:0032722 IDA positive regulation of chemokine production
GO:0032755 IDA positive regulation of interleukin-6 production
GO:0032966 IDA negative regulation of collagen biosynthetic process
GO:0034097 IDA response to cytokine
GO:0042517 IMP positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042803 IPI protein homodimerization activity
GO:0043410 IDA positive regulation of MAPK cascade
GO:0045669 TAS positive regulation of osteoblast differentiation
GO:0048661 IDA positive regulation of smooth muscle cell proliferation
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829 IEP defense response to Gram-negative bacterium
GO:0050830 IEP defense response to Gram-positive bacterium
GO:0070102 IMP interleukin-6-mediated signaling pathway
GO:0070119 IPI ciliary neurotrophic factor binding
GO:0070120 IMP ciliary neurotrophic factor-mediated signaling pathway
GO:0097191 TAS extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070398 il6r interleukin 6 receptor protein_coding Danio_rerio

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