C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cytochrome P450, family 3, subfamily A, polypeptide 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000160868 CYP3A4 9606 - 7:99756960-99784265 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000336411 CYP3A4-001 99757676-99784265 protein_coding
  ENST00000354593 CYP3A4-201 99756960-99784188 protein_coding
  ENST00000415003 CYP3A4-003 99770132-99784184 protein_coding
  ENST00000480043 CYP3A4-002 99769535-99780053 retained_intron

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000336411ENST00000354593ENST00000480043
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000336411 0.019±0.00 N/A 1.141±0.00 N/A 0.467±0.29 0.039±0.03 N/A 271.075±270.95 34.857±34.75 0.104±0.00 0.261±0.24 N/A 0.042±0.00 0.183±0.10
ENST00000354593 N/A 0.043±0.00 N/A 0.010±0.00 0.032±0.00 N/A 0.056±0.04 35.932±35.82 38.863±0.00 N/A 0.016±0.00 0.029±0.02 0.024±0.00 0.064±0.00
ENST00000480043 0.053±0.00 0.045±0.00 N/A 0.024±0.00 N/A N/A N/A N/A N/A N/A N/A 0.057±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005LC CIL_0005LC_0006 CGP 7:99684679-99784265
CIL_0008QI CIL_0008QI_0001 VISTA 7:99696610-100298804
CIL_0005LC CIL_0005LC_0005 CGP 7:99756960-99866102

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004497 ISS monooxygenase activity
GO:0005496 IDA steroid binding
GO:0005506 IDA:IEA iron ion binding
GO:0005737 IDA cytoplasm
GO:0005789 TAS endoplasmic reticulum membrane
GO:0006629 TAS lipid metabolic process
GO:0006706 IMP steroid catabolic process
GO:0006805 TAS xenobiotic metabolic process
GO:0008202 IMP steroid metabolic process
GO:0008209 TAS androgen metabolic process
GO:0008395 IMP steroid hydroxylase activity
GO:0009822 IDA alkaloid catabolic process
GO:0016021 IEA integral component of membrane
GO:0016098 IDA monoterpenoid metabolic process
GO:0016491 IDA oxidoreductase activity
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0017144 IDA drug metabolic process
GO:0019825 TAS oxygen binding
GO:0019899 IPI enzyme binding
GO:0020037 IEA heme binding
GO:0030343 IDA vitamin D3 25-hydroxylase activity
GO:0033780 IEA taurochenodeoxycholate 6alpha-hydroxylase activity
GO:0034875 IDA caffeine oxidase activity
GO:0036378 IDA calcitriol biosynthetic process from calciol
GO:0042359 IC vitamin D metabolic process
GO:0042737 IDA drug catabolic process
GO:0042738 IDA exogenous drug catabolic process
GO:0043231 TAS intracellular membrane-bounded organelle
GO:0044281 TAS small molecule metabolic process
GO:0046483 IDA heterocycle metabolic process
GO:0047638 IEA albendazole monooxygenase activity
GO:0050591 IEA quinine 3-monooxygenase activity
GO:0050649 IMP testosterone 6-beta-hydroxylase activity
GO:0055114 IDA:IEA oxidation-reduction process
GO:0070576 IDA vitamin D 24-hydroxylase activity
GO:0070989 IDA oxidative demethylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015575 cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 protein_coding Danio_rerio
ENSDARG00000037873 cyp3c1l2 cytochrome P450, family 3, subfamily c, polypeptide 1 like, 2 protein_coding Danio_rerio
ENSDARG00000037874 si:dkey-21n8.3 si:dkey-21n8.3 protein_coding Danio_rerio
ENSDARG00000045627 cyp3a65 cytochrome P450, family 3, subfamily A, polypeptide 65 protein_coding Danio_rerio
ENSDARG00000070021 cyp3c4 cytochrome P450, family 3, subfamily C, polypeptide 4 protein_coding Danio_rerio
ENSMUSG00000029630 Cyp3a25 cytochrome P450, family 3, subfamily a, polypeptide 25 protein_coding Mus_musculus
ENSMUSG00000029727 Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 protein_coding Mus_musculus
ENSMUSG00000038656 Cyp3a16 cytochrome P450, family 3, subfamily a, polypeptide 16 protein_coding Mus_musculus
ENSMUSG00000054417 Cyp3a44 cytochrome P450, family 3, subfamily a, polypeptide 44 protein_coding Mus_musculus
ENSMUSG00000056035 Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 protein_coding Mus_musculus
ENSMUSG00000061292 Cyp3a59 cytochrome P450, family 3, subfamily a, polypeptide 59 protein_coding Mus_musculus
ENSMUSG00000070419 Cyp3a57 cytochrome P450, family 3, subfamily a, polypeptide 57 protein_coding Mus_musculus
ENSMUSG00000075551 Cyp3a41a cytochrome P450, family 3, subfamily a, polypeptide 41A protein_coding Mus_musculus
ENSMUSG00000075552 Cyp3a41b cytochrome P450, family 3, subfamily a, polypeptide 41B protein_coding Mus_musculus

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