C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: wingless-type MMTV integration site family, member 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000162552 WNT4 9606 - 1:22117305-22143969 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000290167 WNT4-001 22117305-22142966 protein_coding
  ENST00000415567 WNT4-002 22127038-22129851 protein_coding
  ENST00000441048 WNT4-003 22127474-22143969 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000290167ENST00000415567ENST00000441048
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000290167 0.052±0.00 0.095±0.00 0.025±0.00 0.382±0.27 0.681±0.04 0.426±0.04 0.026±0.00 0.283±0.23 0.250±0.00 0.336±0.17 0.537±0.31 10.991±14.43 5.504±1.68 0.785±0.30
ENST00000415567 N/A N/A N/A 0.131±0.00 N/A N/A N/A N/A N/A N/A N/A 1.298±0.00 N/A N/A
ENST00000441048 N/A N/A N/A N/A N/A N/A N/A N/A 0.064±0.00 N/A N/A 2.175±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001656 IEA metanephros development
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0001822 IEP kidney development
GO:0001823 IEA mesonephros development
GO:0001837 IEP epithelial to mesenchymal transition
GO:0001838 IEA embryonic epithelial tube formation
GO:0001889 IEP liver development
GO:0003714 ISS transcription corepressor activity
GO:0005102 IEA receptor binding
GO:0005109 IBA frizzled binding
GO:0005515 IEA protein binding
GO:0005576 TAS:IEA extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IDA extracellular space
GO:0005737 IDA cytoplasm
GO:0005788 TAS endoplasmic reticulum lumen
GO:0005796 TAS Golgi lumen
GO:0005886 TAS plasma membrane
GO:0006702 IDA androgen biosynthetic process
GO:0007275 IEA multicellular organismal development
GO:0007276 IEA gamete generation
GO:0007548 IEA sex differentiation
GO:0008584 IMP male gonad development
GO:0008585 ISS female gonad development
GO:0009267 IEA cellular response to starvation
GO:0009986 ISS cell surface
GO:0010629 IDA negative regulation of gene expression
GO:0010894 IDA negative regulation of steroid biosynthetic process
GO:0016055 IEA Wnt signaling pathway
GO:0018345 IDA protein palmitoylation
GO:0022407 IEA regulation of cell-cell adhesion
GO:0030154 IEA cell differentiation
GO:0030182 IBA neuron differentiation
GO:0030237 IMP female sex determination
GO:0030325 IEP adrenal gland development
GO:0030336 IEA negative regulation of cell migration
GO:0030501 IDA positive regulation of bone mineralization
GO:0031012 IEA extracellular matrix
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0032349 IDA positive regulation of aldosterone biosynthetic process
GO:0032967 IDA positive regulation of collagen biosynthetic process
GO:0033077 IEA T cell differentiation in thymus
GO:0033080 IEA immature T cell proliferation in thymus
GO:0035239 IEA tube morphogenesis
GO:0035567 IEA non-canonical Wnt signaling pathway
GO:0038030 IDA non-canonical Wnt signaling pathway via MAPK cascade
GO:0040037 IEA negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042445 IEA hormone metabolic process
GO:0045165 IBA cell fate commitment
GO:0045596 IEA negative regulation of cell differentiation
GO:0045669 IDA positive regulation of osteoblast differentiation
GO:0045836 IEA positive regulation of meiosis
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0048018 IC receptor agonist activity
GO:0048599 IEA oocyte development
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0048856 IEA anatomical structure development
GO:0051145 IEA smooth muscle cell differentiation
GO:0051496 IEA positive regulation of stress fiber assembly
GO:0051894 IEA positive regulation of focal adhesion assembly
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060126 IEA somatotropin secreting cell differentiation
GO:0060129 IEA thyroid-stimulating hormone-secreting cell differentiation
GO:0060231 IEA mesenchymal to epithelial transition
GO:0060748 IEA tertiary branching involved in mammary gland duct morphogenesis
GO:0060993 IEA kidney morphogenesis
GO:0061045 IEA negative regulation of wound healing
GO:0061180 IEP mammary gland epithelium development
GO:0061184 IDA positive regulation of dermatome development
GO:0061205 IMP paramesonephric duct development
GO:0061369 IMP negative regulation of testicular blood vessel morphogenesis
GO:0071560 IEP cellular response to transforming growth factor beta stimulus
GO:0072033 IEA renal vesicle formation
GO:0072034 IEA renal vesicle induction
GO:0072162 NAS metanephric mesenchymal cell differentiation
GO:0072164 IEA mesonephric tubule development
GO:0072174 IEA metanephric tubule formation
GO:0072210 IEA metanephric nephron development
GO:0072273 IEA metanephric nephron morphogenesis
GO:0090002 IDA establishment of protein localization to plasma membrane
GO:0090090 IDA negative regulation of canonical Wnt signaling pathway
GO:0090263 IDA positive regulation of canonical Wnt signaling pathway
GO:2000019 IMP negative regulation of male gonad development
GO:2000066 IDA positive regulation of cortisol biosynthetic process
GO:2000225 IMP negative regulation of testosterone biosynthetic process
GO:2001234 IEA negative regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071208 wnt4a wingless-type MMTV integration site family, member 4a protein_coding Danio_rerio
ENSMUSG00000036856 Wnt4 wingless-type MMTV integration site family, member 4 protein_coding Mus_musculus

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