C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cytotoxic T-lymphocyte-associated protein 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000163599 CTLA4 9606 + 2:203867786-203873960 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000295854 CTLA4-005 203867943-203872775 protein_coding
  ENST00000302823 CTLA4-001 203867786-203873960 protein_coding
  ENST00000427473 CTLA4-002 203870232-203873185 protein_coding
  ENST00000472206 CTLA4-004 203867943-203872812 protein_coding
  ENST00000487393 CTLA4-003 203867943-203872812 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastHeartLiverLungOvaryPlacentaTestisENST00000295854ENST00000302823ENST00000427473
Transcript ID Adipose Adrenal Brain Breast Heart Liver Lung Ovary Placenta Testis
ENST00000295854 N/A N/A N/A N/A 0.136±0.00 N/A 1.625±0.00 0.189±0.00 N/A N/A
ENST00000302823 0.046±0.00 0.499±0.00 0.122±0.00 0.488±0.00 0.040±0.00 0.010±0.00 N/A 0.276±0.20 0.084±0.03 0.290±0.12
ENST00000427473 N/A N/A N/A N/A N/A N/A N/A 0.364±0.09 0.043±0.00 0.397±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000398 CIL_000398_0001 CGP 2:203706475-203873960
CIL_00039C CIL_00039C_0001 CGP 2:203867786-203961577

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005794 IDA Golgi apparatus
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006955 IEA immune response
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0009897 IDA external side of plasma membrane
GO:0030889 IMP negative regulation of B cell proliferation
GO:0031295 TAS T cell costimulation
GO:0042130 IEA negative regulation of T cell proliferation
GO:0043065 IMP positive regulation of apoptotic process
GO:0045334 IDA clathrin-coated endocytic vesicle
GO:0045590 IDA negative regulation of regulatory T cell differentiation
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050777 IEA negative regulation of immune response
GO:0050853 IMP B cell receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000026011 Ctla4 cytotoxic T-lymphocyte-associated protein 4 protein_coding Mus_musculus

Loading