C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: paired-like homeodomain 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164093 PITX2 9606 - 4:110617423-110642123 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000306732 PITX2-005 110617423-110623103 protein_coding
  ENST00000354925 PITX2-003 110617426-110642006 protein_coding
  ENST00000355080 PITX2-002 110617423-110637352 protein_coding
  ENST00000394595 PITX2-004 110617436-110637026 protein_coding
  ENST00000394598 PITX2-001 110617423-110637020 protein_coding
  ENST00000511837 PITX2-006 110618209-110642123 protein_coding
  ENST00000511990 PITX2-007 110618586-110642016 protein_coding
  ENST00000556049 PITX2-008 110618465-110620716 processed_transcript
  ENST00000557119 PITX2-010 110620277-110623051 protein_coding
  ENST00000607868 PITX2-009 110617429-110618826 retained_intron
  ENST00000613094 PITX2-201 110617428-110642123 protein_coding
  ENST00000614423 PITX2-202 110617428-110642123 protein_coding
  ENST00000616641 PITX2-203 110617428-110642123 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000306732ENST00000394598ENST00000511837ENST00000511990ENST00000556049ENST00000557119ENST00000607868
Transcript ID Adipose Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000306732 N/A N/A 0.657±0.00 0.175±0.00 0.023±0.00 0.414±0.00 1.466±0.00 N/A 7.504±6.07 N/A 12.235±8.56 1.096±0.00
ENST00000394598 N/A N/A 0.275±0.00 0.184±0.05 N/A N/A N/A N/A N/A N/A 12.679±5.58 0.435±0.00
ENST00000511837 N/A N/A 0.167±0.00 0.481±0.00 0.021±0.00 N/A N/A N/A N/A 0.362±0.00 N/A 0.391±0.00
ENST00000511990 N/A N/A N/A N/A N/A N/A N/A N/A 3.916±0.00 N/A N/A N/A
ENST00000556049 N/A N/A 0.357±0.00 N/A N/A N/A N/A 0.286±0.00 N/A N/A N/A N/A
ENST00000557119 N/A 0.024±0.00 N/A 0.273±0.00 N/A N/A N/A N/A N/A 0.029±0.00 N/A 0.256±0.00
ENST00000607868 0.048±0.00 N/A 0.440±0.07 N/A 0.018±0.00 N/A N/A 0.479±0.00 N/A 0.180±0.19 19.797±0.00 0.737±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000917 CIL_000917_0001 VISTA 4:110309018-110909617
CIL_000912 CIL_000912_0001 VISTA 4:110357117-110957671
CIL_0007ZJ CIL_0007ZJ_0001 VISTA 4:110448103-111050012
CIL_0007RD CIL_0007RD_0001 VISTA 4:110613299-111214576

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000976 IDA transcription regulatory region sequence-specific DNA binding
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0001105 IDA RNA polymerase II transcription coactivator activity
GO:0001191 IDA RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0001569 IEA patterning of blood vessels
GO:0001570 IEA vasculogenesis
GO:0001701 IEA in utero embryonic development
GO:0001764 IEA neuron migration
GO:0002074 IEA extraocular skeletal muscle development
GO:0003171 IEA atrioventricular valve development
GO:0003253 ISS cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003350 IEA pulmonary myocardium development
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0005737 IEA cytoplasm
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007368 ISS determination of left/right symmetry
GO:0007420 IEA brain development
GO:0007507 IEA heart development
GO:0007519 IEA skeletal muscle tissue development
GO:0007520 IEA myoblast fusion
GO:0008134 IPI transcription factor binding
GO:0008584 IEA male gonad development
GO:0008585 IEA female gonad development
GO:0009653 IEA anatomical structure morphogenesis
GO:0009725 IEA response to hormone
GO:0009887 IEA organ morphogenesis
GO:0016055 IEA Wnt signaling pathway
GO:0021763 IEA subthalamic nucleus development
GO:0021855 IEA hypothalamus cell migration
GO:0021983 IEA pituitary gland development
GO:0030182 IEA neuron differentiation
GO:0030324 IEA lung development
GO:0030334 IEA regulation of cell migration
GO:0031076 IEA embryonic camera-type eye development
GO:0031490 IEA chromatin DNA binding
GO:0033189 IEA response to vitamin A
GO:0035116 IEA embryonic hindlimb morphogenesis
GO:0035315 IC hair cell differentiation
GO:0035886 IEA vascular smooth muscle cell differentiation
GO:0035993 IMP deltoid tuberosity development
GO:0042127 IEA regulation of cell proliferation
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042476 IMP odontogenesis
GO:0042803 IPI protein homodimerization activity
GO:0043010 IMP camera-type eye development
GO:0043021 IC ribonucleoprotein complex binding
GO:0043388 IEA positive regulation of DNA binding
GO:0043565 IEA sequence-specific DNA binding
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048536 ISS spleen development
GO:0048557 IEA embryonic digestive tract morphogenesis
GO:0048738 IEA cardiac muscle tissue development
GO:0051219 IPI phosphoprotein binding
GO:0055007 IEA cardiac muscle cell differentiation
GO:0055009 IEA atrial cardiac muscle tissue morphogenesis
GO:0055015 IEA ventricular cardiac muscle cell development
GO:0055123 IEA digestive system development
GO:0060126 TAS somatotropin secreting cell differentiation
GO:0060127 TAS prolactin secreting cell differentiation
GO:0060412 IEA ventricular septum morphogenesis
GO:0060460 IEA left lung morphogenesis
GO:0060577 IEA pulmonary vein morphogenesis
GO:0060578 IEA superior vena cava morphogenesis
GO:0061031 IEA endodermal digestive tract morphogenesis
GO:0061072 IMP iris morphogenesis
GO:0061325 ISS cell proliferation involved in outflow tract morphogenesis
GO:0070986 ISS left/right axis specification
GO:2000288 IEA positive regulation of myoblast proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000028023 Pitx2 paired-like homeodomain transcription factor 2 protein_coding Mus_musculus

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