C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: heart and neural crest derivatives expressed 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164107 HAND2 9606 - 4:173524969-173530229 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359562 HAND2-001 173526091-173530229 protein_coding
  ENST00000503024 HAND2-006 173524969-173528912 nonsense_mediated_decay
  ENST00000505300 HAND2-003 173528079-173530206 processed_transcript
  ENST00000621866 HAND2-201 173526501-173529289 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359562ENST00000621866
Transcript ID Adipose Adrenal Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359562 0.333±0.00 N/A 0.641±0.00 41.808±0.00 13.836±7.37 0.693±0.64 3.361±2.15 N/A N/A 5.376±2.90 14.338±7.46 1.533±1.25
ENST00000621866 N/A 0.448±0.00 1.018±0.00 1.653±0.00 N/A N/A 2.561±0.00 0.483±0.00 0.095±0.00 7.886±6.35 29.715±15.35 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008VG CIL_0008VG_0001 VISTA 4:173198350-173802625
CIL_0008BZ CIL_0008BZ_0001 VISTA 4:173215162-173815719
CIL_00080O CIL_00080O_0001 VISTA 4:173380161-173984834
CIL_00007S CIL_00007S_0002 CGP 4:173524969-174284264

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IDA nuclear chromatin
GO:0000977 IDA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001525 IEA angiogenesis
GO:0001701 ISS in utero embryonic development
GO:0001947 ISS heart looping
GO:0001967 IEA suckling behavior
GO:0003007 ISS heart morphogenesis
GO:0003219 IEA cardiac right ventricle formation
GO:0003253 IEA cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003266 ISS regulation of secondary heart field cardioblast proliferation
GO:0003278 IEA apoptotic process involved in heart morphogenesis
GO:0003357 NAS noradrenergic neuron differentiation
GO:0003680 IDA AT DNA binding
GO:0003713 ISS transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005667 ISS transcription factor complex
GO:0006351 IEA transcription, DNA-templated
GO:0006355 ISS regulation of transcription, DNA-templated
GO:0006915 ISS apoptotic process
GO:0007507 NAS heart development
GO:0007512 IEP adult heart development
GO:0008134 ISS transcription factor binding
GO:0010463 IEA mesenchymal cell proliferation
GO:0010667 ISS negative regulation of cardiac muscle cell apoptotic process
GO:0014032 ISS neural crest cell development
GO:0033613 ISS activating transcription factor binding
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042733 IEA embryonic digit morphogenesis
GO:0042803 ISS protein homodimerization activity
GO:0043066 IEA negative regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043392 IEA negative regulation of DNA binding
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IEA sequence-specific DNA binding
GO:0043586 IEA tongue development
GO:0044212 ISS transcription regulatory region DNA binding
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0046983 IEA protein dimerization activity
GO:0048485 IEA sympathetic nervous system development
GO:0048538 ISS thymus development
GO:0048935 IEA peripheral nervous system neuron development
GO:0060021 IEA palate development
GO:0060485 IEA mesenchyme development
GO:0060536 IEA cartilage morphogenesis
GO:0060982 IEA coronary artery morphogenesis
GO:0061032 IEA visceral serous pericardium development
GO:0061309 ISS cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061325 IEA cell proliferation involved in outflow tract morphogenesis
GO:0061371 IEA determination of heart left/right asymmetry
GO:0070888 IDA E-box binding
GO:2000679 IDA positive regulation of transcription regulatory region DNA binding
GO:2000763 ISS positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process
GO:2000764 ISS positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008305 hand2 heart and neural crest derivatives expressed transcript 2 protein_coding Danio_rerio
ENSMUSG00000038193 Hand2 heart and neural crest derivatives expressed transcript 2 protein_coding Mus_musculus

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