C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: caspase 3, apoptosis-related cysteine peptidase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164305 CASP3 9606 - 4:184627696-184649509 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000308394 CASP3-001 184627696-184649475 protein_coding
  ENST00000393585 CASP3-002 184627696-184648592 protein_coding
  ENST00000393588 CASP3-005 184629384-184649455 protein_coding
  ENST00000447121 CASP3-004 184631896-184649447 protein_coding
  ENST00000517513 CASP3-006 184629256-184649447 protein_coding
  ENST00000523916 CASP3-003 184627696-184649509 protein_coding
  ENST00000613118 CASP3-201 184627697-184648592 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000308394ENST00000523916ENST00000613118
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000308394 2.571±0.00 1.619±0.00 N/A 1.200±0.00 2.291±0.00 N/A 1.036±0.00 1.457±0.75 0.712±0.33 N/A N/A 2.974±0.49 3.908±0.77 1.512±0.21
ENST00000523916 2.201±0.00 4.389±0.00 0.729±0.00 4.014±0.00 1.903±0.91 2.527±0.78 1.717±0.00 1.423±1.13 2.055±0.36 1.250±0.64 1.873±0.00 11.483±11.84 5.846±5.66 4.782±0.09
ENST00000613118 N/A N/A N/A N/A 0.647±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00094W CIL_00094W_0001 VISTA 4:184083896-184687060
CIL_00097G CIL_00097G_0001 VISTA 4:184147184-184748475
CIL_0000GX CIL_0000GX_0002 CGP 4:184387713-184649509

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001782 IEA B cell homeostasis
GO:0001836 IEA release of cytochrome c from mitochondria
GO:0004190 EXP aspartic-type endopeptidase activity
GO:0004197 IDA:IEA cysteine-type endopeptidase activity
GO:0004861 IEA cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005829 IDA cytosol
GO:0005886 TAS plasma membrane
GO:0006309 TAS apoptotic DNA fragmentation
GO:0006508 IEA:IDA proteolysis
GO:0006915 TAS:IEA apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007507 IEA heart development
GO:0007605 IEA sensory perception of sound
GO:0008233 IDA peptidase activity
GO:0008234 IEA cysteine-type peptidase activity
GO:0008625 IEA extrinsic apoptotic signaling pathway via death domain receptors
GO:0008631 IEA intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008635 TAS activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009411 IEA response to UV
GO:0009611 IEA response to wounding
GO:0016485 IEA protein processing
GO:0022617 TAS extracellular matrix disassembly
GO:0030182 IBA neuron differentiation
GO:0030198 TAS extracellular matrix organization
GO:0030216 IBA keratinocyte differentiation
GO:0030218 IDA erythrocyte differentiation
GO:0030220 TAS platelet formation
GO:0030889 IEA negative regulation of B cell proliferation
GO:0034349 IEA glial cell apoptotic process
GO:0034612 TAS response to tumor necrosis factor
GO:0035329 TAS hippo signaling
GO:0042981 TAS regulation of apoptotic process
GO:0043029 IEA T cell homeostasis
GO:0043065 TAS positive regulation of apoptotic process
GO:0043066 IGI negative regulation of apoptotic process
GO:0043281 TAS regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0045165 IEA cell fate commitment
GO:0045736 IEA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786 IEA negative regulation of cell cycle
GO:0046007 IEA negative regulation of activated T cell proliferation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051402 IEA neuron apoptotic process
GO:0071310 IEA cellular response to organic substance
GO:0097153 IMP cysteine-type endopeptidase activity involved in apoptotic process
GO:0097190 TAS apoptotic signaling pathway
GO:0097192 IEA extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:0097194 IMP execution phase of apoptosis
GO:0097200 IMP cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902510 IEA regulation of apoptotic DNA fragmentation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017905 casp3a caspase 3, apoptosis-related cysteine protease a protein_coding Danio_rerio
ENSDARG00000055045 casp3b caspase 3, apoptosis-related cysteine protease b protein_coding Danio_rerio
ENSMUSG00000031628 Casp3 caspase 3 protein_coding Mus_musculus

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