C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: G protein-coupled estrogen receptor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164850 GPER1 9606 + 7:1082208-1093815 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000297469 GPER1-030 1086876-1093815 protein_coding
  ENST00000397088 GPER1-031 1088087-1093810 protein_coding
  ENST00000397092 GPER1-201 1086807-1093815 protein_coding
  ENST00000401670 GPER1-032 1082208-1092881 protein_coding
  ENST00000413368 GPER1-033 1086807-1091949 protein_coding
  ENST00000617001 GPER1-202 1091628-1093809 protein_coding
  ENST00000619052 GPER1-203 1092938-1093741 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000297469ENST00000397088ENST00000397092ENST00000401670ENST00000413368ENST00000617001ENST00000619052
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000297469 0.271±0.00 1.264±0.00 N/A 0.746±0.00 1.567±0.00 1.421±0.00 N/A 1.118±0.00 N/A N/A N/A 0.518±0.07 1.814±0.53 0.609±0.35
ENST00000397088 N/A 2.506±0.00 0.300±0.00 0.740±0.31 4.969±0.00 1.779±1.34 1.082±0.00 2.014±0.58 3.624±3.11 1.443±1.07 N/A 0.984±0.05 4.874±2.95 1.081±0.55
ENST00000397092 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.652±0.00 2.100±0.00 N/A
ENST00000401670 0.596±0.00 N/A N/A N/A N/A 1.071±0.00 0.595±0.00 N/A N/A N/A 0.163±0.00 N/A N/A N/A
ENST00000413368 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.293±0.00
ENST00000617001 1.113±0.00 N/A N/A 1.061±0.40 2.125±1.45 2.926±0.00 0.531±0.00 N/A 1.642±0.88 0.722±0.40 N/A 0.897±0.69 2.448±1.45 0.877±0.00
ENST00000619052 N/A N/A N/A N/A N/A N/A 1.047±0.00 N/A N/A 0.768±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008V5 CIL_0008V5_0001 VISTA 7:925518-1526682
CIL_0008DL CIL_0008DL_0001 VISTA 7:928196-1529533
CIL_0000ZU CIL_0000ZU_0001 CGP 7:983199-1138260
CIL_0000ZR CIL_0000ZR_0001 CGP 7:996986-1138260
CIL_0002HC CIL_0002HC_0002 CGP 7:1044576-1093815
CIL_0000ZS CIL_0000ZS_0001 CGP 7:1082208-1160759

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0001956 ISS positive regulation of neurotransmitter secretion
GO:0002695 IDA negative regulation of leukocyte activation
GO:0003682 IDA chromatin binding
GO:0004930 IEA G-protein coupled receptor activity
GO:0005496 IDA steroid binding
GO:0005515 IPI protein binding
GO:0005622 ISS intracellular
GO:0005634 IDA nucleus
GO:0005635 IDA nuclear envelope
GO:0005737 ISS cytoplasm
GO:0005769 IDA early endosome
GO:0005783 IDA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005802 IDA trans-Golgi network
GO:0005886 IDA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006954 IEA inflammatory response
GO:0007049 IEA cell cycle
GO:0007186 TAS:IEA G-protein coupled receptor signaling pathway
GO:0007204 ISS positive regulation of cytosolic calcium ion concentration
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0010579 IDA positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010628 ISS positive regulation of gene expression
GO:0010629 ISS negative regulation of gene expression
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 ISS postsynaptic density
GO:0016021 IEA integral component of membrane
GO:0017082 ISS mineralocorticoid receptor activity
GO:0019228 ISS neuronal action potential
GO:0030054 IEA cell junction
GO:0030263 ISS apoptotic chromosome condensation
GO:0030264 ISS nuclear fragmentation involved in apoptotic nuclear change
GO:0030284 IDA estrogen receptor activity
GO:0030335 IMP positive regulation of cell migration
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0030518 IDA intracellular steroid hormone receptor signaling pathway
GO:0030659 IDA cytoplasmic vesicle membrane
GO:0030819 IDA positive regulation of cAMP biosynthetic process
GO:0031959 ISS mineralocorticoid receptor signaling pathway
GO:0031966 ISS mitochondrial membrane
GO:0032024 ISS positive regulation of insulin secretion
GO:0032591 ISS dendritic spine membrane
GO:0032962 IDA positive regulation of inositol trisphosphate biosynthetic process
GO:0042734 ISS presynaptic membrane
GO:0043065 ISS positive regulation of apoptotic process
GO:0043198 ISS dendritic shaft
GO:0043280 ISS positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401 IDA steroid hormone mediated signaling pathway
GO:0043410 ISS positive regulation of MAPK cascade
GO:0043679 ISS axon terminus
GO:0044327 ISS dendritic spine head
GO:0045087 IEA innate immune response
GO:0045095 IDA keratin filament
GO:0045599 ISS negative regulation of fat cell differentiation
GO:0045742 IDA positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745 IDA positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045909 ISS positive regulation of vasodilation
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048786 ISS presynaptic active zone
GO:0050728 IDA negative regulation of inflammatory response
GO:0050769 ISS positive regulation of neurogenesis
GO:0051053 ISS negative regulation of DNA metabolic process
GO:0051055 ISS negative regulation of lipid biosynthetic process
GO:0051281 IDA positive regulation of release of sequestered calcium ion into cytosol
GO:0051480 ISS cytosolic calcium ion homeostasis
GO:0055037 IDA recycling endosome
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0070474 IDA positive regulation of uterine smooth muscle contraction
GO:0071157 ISS negative regulation of cell cycle arrest
GO:0071333 ISS cellular response to glucose stimulus
GO:0071356 IDA cellular response to tumor necrosis factor
GO:0071375 IDA cellular response to peptide hormone stimulus
GO:0071389 ISS cellular response to mineralocorticoid stimulus
GO:0071392 IDA cellular response to estradiol stimulus
GO:0090004 IDA positive regulation of establishment of protein localization to plasma membrane
GO:0090200 ISS positive regulation of release of cytochrome c from mitochondria
GO:0097481 ISS neuronal postsynaptic density
GO:2000353 ISS positive regulation of endothelial cell apoptotic process
GO:2001238 ISS positive regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074661 gper1 G protein-coupled estrogen receptor 1 protein_coding Danio_rerio
ENSMUSG00000053647 Gper1 G protein-coupled estrogen receptor 1 protein_coding Mus_musculus

Loading