C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: caspase 7, apoptosis-related cysteine peptidase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000165806 CASP7 9606 + 10:113679162-113730907 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000345633 CASP7-005 113679669-113730903 protein_coding
  ENST00000369315 CASP7-002 113679940-113730903 protein_coding
  ENST00000369318 CASP7-001 113679877-113730903 protein_coding
  ENST00000369321 CASP7-201 113679669-113730907 protein_coding
  ENST00000369331 CASP7-003 113679204-113730896 protein_coding
  ENST00000429617 CASP7-004 113679183-113726419 protein_coding
  ENST00000452490 CASP7-202 113709345-113730907 protein_coding
  ENST00000468790 CASP7-007 113719210-113721686 processed_transcript
  ENST00000487232 CASP7-008 113720998-113729503 retained_intron
  ENST00000614447 CASP7-203 113679669-113730907 protein_coding
  ENST00000621345 CASP7-204 113679162-113730907 protein_coding
  ENST00000621607 CASP7-205 113691972-113730907 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000345633ENST00000369315ENST00000369318ENST00000369321ENST00000369331ENST00000429617ENST00000452490ENST00000468790ENST00000487232ENST00000614447ENST00000621345ENST00000621607
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000345633 N/A 0.952±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.540±0.00
ENST00000369315 1.540±0.00 N/A N/A N/A 1.406±0.00 N/A N/A 1.670±0.00 1.036±0.00 N/A N/A N/A N/A N/A
ENST00000369318 8.680±0.00 2.280±0.00 N/A 0.811±0.00 4.199±1.93 3.689±0.54 0.752±0.39 4.546±2.49 2.397±0.00 9.868±8.10 0.857±0.14 6.572±0.87 4.972±1.27 1.843±0.00
ENST00000369321 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.084±0.00 N/A 0.929±0.04
ENST00000369331 N/A 1.952±0.00 N/A 1.335±0.00 3.758±0.00 N/A 1.368±0.00 3.740±0.00 N/A N/A 2.104±0.00 4.113±0.00 1.874±0.00 1.984±1.17
ENST00000429617 N/A N/A 1.922±0.00 0.231±0.00 2.379±0.00 N/A 0.752±0.00 N/A 1.388±0.00 4.683±0.00 0.880±0.00 N/A N/A N/A
ENST00000452490 N/A N/A N/A 0.575±0.02 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.336±0.00
ENST00000468790 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.118±2.15 N/A N/A
ENST00000487232 N/A N/A N/A 0.356±0.00 3.433±0.00 N/A 1.159±0.00 N/A 1.083±0.00 N/A 1.626±0.44 N/A N/A N/A
ENST00000614447 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.726±0.00 3.151±0.00 0.450±0.00
ENST00000621345 2.490±0.00 N/A 1.056±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 2.498±1.26 1.819±0.22 N/A
ENST00000621607 N/A 1.402±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.032±0.00 0.793±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002GC CIL_0002GC_0001 CGP 10:113588716-113730907
CIL_0006OY CIL_0006OY_0001 CGP 10:113679162-113783429

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001836 IEA release of cytochrome c from mitochondria
GO:0004190 IEA aspartic-type endopeptidase activity
GO:0004197 IBA:IEA cysteine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 TAS cytoplasm
GO:0005829 IDA cytosol
GO:0006508 IDA:IEA proteolysis
GO:0006915 TAS:IEA apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0007507 IEA heart development
GO:0007568 IEA aging
GO:0008234 TAS:IEA cysteine-type peptidase activity
GO:0008635 TAS activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009411 IEA response to UV
GO:0016485 IEA protein processing
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0097153 IEA cysteine-type endopeptidase activity involved in apoptotic process
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:0097194 IBA execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000091836 casp7 caspase 7, apoptosis-related cysteine peptidase protein_coding Danio_rerio
ENSMUSG00000025076 Casp7 caspase 7 protein_coding Mus_musculus

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