C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: polo-like kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166851 PLK1 9606 + 16:23677656-23690367 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000300093 PLK1-001 23678822-23690367 protein_coding
  ENST00000562272 PLK1-002 23677656-23690366 retained_intron
  ENST00000562407 PLK1-003 23683902-23687820 retained_intron
  ENST00000564202 PLK1-006 23678971-23681054 processed_transcript
  ENST00000564794 PLK1-010 23688676-23690038 retained_intron
  ENST00000564947 PLK1-005 23687137-23688732 retained_intron
  ENST00000567897 PLK1-007 23679583-23684089 protein_coding
  ENST00000568568 PLK1-008 23679732-23683948 protein_coding
  ENST00000570220 PLK1-004 23678869-23681022 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastHeartKidneyLiverLungOvaryPlacentaTestisENST00000300093ENST00000562272ENST00000564202ENST00000564794ENST00000567897ENST00000568568ENST00000570220
Transcript ID Adipose Adrenal Bladder Brain Breast Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000300093 0.259±0.00 N/A N/A N/A 0.266±0.00 0.210±0.00 N/A 0.101±0.00 0.360±0.00 5.157±5.85 7.005±2.37 24.730±3.24
ENST00000562272 0.077±0.00 0.344±0.00 0.076±0.00 0.664±0.00 N/A N/A 0.500±0.00 0.040±0.00 N/A 0.488±0.00 N/A N/A
ENST00000564202 N/A N/A N/A N/A N/A 0.495±0.00 N/A N/A N/A N/A N/A N/A
ENST00000564794 N/A 1.490±0.00 N/A 1.200±0.00 N/A N/A N/A 0.442±0.00 N/A 21.786±0.00 9.175±0.00 35.441±0.00
ENST00000567897 N/A N/A N/A N/A N/A N/A N/A N/A 0.963±0.00 N/A N/A N/A
ENST00000568568 N/A N/A N/A 0.191±0.00 0.800±0.00 N/A 0.338±0.00 N/A N/A N/A N/A N/A
ENST00000570220 N/A N/A N/A 0.464±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006D0 CIL_0006D0_0001 CGP 16:23641392-23690367
CIL_0003VD CIL_0003VD_0002 CGP 16:23677656-23713500

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000070 IMP mitotic sister chromatid segregation
GO:0000086 IDA G2/M transition of mitotic cell cycle
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000278 TAS mitotic cell cycle
GO:0000281 IDA mitotic cytokinesis
GO:0000776 IDA kinetochore
GO:0000910 IMP cytokinesis
GO:0000922 IDA spindle pole
GO:0000942 IDA condensed nuclear chromosome outer kinetochore
GO:0001578 IDA microtubule bundle formation
GO:0004672 IEA:IDA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005819 IDA spindle
GO:0005829 TAS cytosol
GO:0005876 IDA spindle microtubule
GO:0006468 IEA:IDA protein phosphorylation
GO:0007067 IMP mitotic nuclear division
GO:0007077 TAS mitotic nuclear envelope disassembly
GO:0007091 TAS metaphase/anaphase transition of mitotic cell cycle
GO:0007092 IDA activation of mitotic anaphase-promoting complex activity
GO:0007094 IMP mitotic spindle assembly checkpoint
GO:0007346 IMP regulation of mitotic cell cycle
GO:0008017 IDA microtubule binding
GO:0008283 TAS cell proliferation
GO:0010800 IMP positive regulation of peptidyl-threonine phosphorylation
GO:0010997 IPI anaphase-promoting complex binding
GO:0015630 IDA microtubule cytoskeleton
GO:0016301 TAS kinase activity
GO:0016567 IDA protein ubiquitination
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0030071 IMP regulation of mitotic metaphase/anaphase transition
GO:0030496 IDA midbody
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031572 IDA G2 DNA damage checkpoint
GO:0031648 IDA protein destabilization
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0040038 IEA polar body extrusion after meiotic divisions
GO:0043066 IMP negative regulation of apoptotic process
GO:0043393 IMP regulation of protein binding
GO:0045184 IMP establishment of protein localization
GO:0045736 IMP negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045862 IDA positive regulation of proteolysis
GO:0046677 IEA response to antibiotic
GO:0051233 IDA spindle midzone
GO:0051297 IMP centrosome organization
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051443 IMP positive regulation of ubiquitin-protein transferase activity
GO:0051726 TAS regulation of cell cycle
GO:0071168 IDA protein localization to chromatin

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058471 plk1 polo-like kinase 1 (Drosophila) protein_coding Danio_rerio
ENSMUSG00000030867 Plk1 polo-like kinase 1 protein_coding Mus_musculus

Loading