C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DIS3 like exosome 3'-5' exoribonuclease
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166938 DIS3L 9606 + 15:66293217-66333898 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000319194 DIS3L-001 66293217-66333898 protein_coding
  ENST00000319212 DIS3L-004 66293547-66333744 protein_coding
  ENST00000524795 DIS3L-002 66293307-66325988 nonsense_mediated_decay
  ENST00000525109 DIS3L-009 66293639-66315074 protein_coding
  ENST00000525134 DIS3L-005 66293291-66306950 protein_coding
  ENST00000530537 DIS3L-003 66295097-66333728 nonsense_mediated_decay
  ENST00000530615 DIS3L-007 66294059-66308827 protein_coding
  ENST00000532293 DIS3L-008 66293843-66295073 processed_transcript
  ENST00000532580 DIS3L-006 66293832-66308844 protein_coding
  ENST00000562314 DIS3L-014 66306820-66311901 retained_intron
  ENST00000564909 DIS3L-012 66293596-66326561 retained_intron
  ENST00000564945 DIS3L-013 66328997-66329548 retained_intron
  ENST00000565281 DIS3L-011 66293501-66326451 retained_intron
  ENST00000568874 DIS3L-015 66329280-66330024 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000319194ENST00000319212ENST00000530537ENST00000564909
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000319194 3.521±0.00 3.251±0.00 0.675±0.00 3.143±0.00 4.953±0.00 1.551±0.00 1.587±0.00 2.529±0.00 1.969±0.00 0.659±0.00 4.583±0.00 4.435±3.11 N/A 5.777±0.00
ENST00000319212 1.147±0.00 N/A N/A N/A 2.266±0.00 1.665±0.11 2.183±0.00 0.504±0.00 1.062±0.02 N/A 2.480±0.00 1.320±0.30 1.103±0.12 N/A
ENST00000530537 2.156±0.00 3.542±0.00 1.526±0.00 6.330±1.06 3.218±1.27 1.322±0.49 4.028±0.00 2.933±1.56 1.437±0.44 1.404±0.05 3.569±0.82 3.382±1.20 3.113±1.33 7.323±1.36
ENST00000564909 N/A N/A N/A N/A N/A N/A 3.388±0.00 2.172±0.00 N/A 0.728±0.00 N/A 1.452±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000175 IMP 3'-5'-exoribonuclease activity
GO:0000177 IDA cytoplasmic exosome (RNase complex)
GO:0003723 IEA RNA binding
GO:0005515 IPI protein binding
GO:0016075 IMP rRNA catabolic process
GO:0019899 IPI enzyme binding
GO:0090503 IMP RNA phosphodiester bond hydrolysis, exonucleolytic

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053200 dis3l DIS3 mitotic control homolog (S. cerevisiae)-like protein_coding Danio_rerio
ENSMUSG00000032396 Dis3l DIS3 mitotic control homolog (S. cerevisiae)-like protein_coding Mus_musculus

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