C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: G protein-coupled receptor, class C, group 5, member B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167191 GPRC5B 9606 - 16:19856691-19886167 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000300571 GPRC5B-001 19856691-19884917 protein_coding
  ENST00000535671 GPRC5B-004 19858498-19872845 protein_coding
  ENST00000562348 GPRC5B-005 19858971-19862340 retained_intron
  ENST00000562469 GPRC5B-009 19872401-19884904 protein_coding
  ENST00000564449 GPRC5B-006 19872769-19885525 protein_coding
  ENST00000566822 GPRC5B-008 19872313-19882360 protein_coding
  ENST00000568214 GPRC5B-010 19872576-19886155 protein_coding
  ENST00000569102 GPRC5B-011 19857299-19858046 processed_transcript
  ENST00000569479 GPRC5B-002 19858971-19886167 protein_coding
  ENST00000569847 GPRC5B-003 19860408-19885727 protein_coding
  ENST00000570142 GPRC5B-007 19872587-19884864 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000300571ENST00000562348ENST00000569479
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000300571 20.332±0.00 20.754±0.00 4.900±0.00 42.797±31.11 7.866±6.77 5.069±3.95 6.436±4.99 18.563±0.00 1.895±0.59 6.451±0.00 15.685±9.84 15.877±3.44 8.365±0.17 32.855±1.63
ENST00000562348 N/A 25.399±0.00 N/A 65.845±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000569479 19.642±0.00 N/A N/A 148.995±0.00 N/A 16.037±0.00 9.502±0.00 20.038±0.00 N/A N/A 14.900±0.00 20.803±0.00 15.216±0.30 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006MO CIL_0006MO_0001 CGP 16:19701934-19858467
CIL_00008S CIL_00008S_0002 CGP 16:19716456-19886167
CIL_0006MP CIL_0006MP_0001 CGP 16:19856691-20073917

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001664 ISS G-protein coupled receptor binding
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0004930 IEA G-protein coupled receptor activity
GO:0005615 IDA extracellular space
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0005886 IEA plasma membrane
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007626 IEA locomotory behavior
GO:0009986 ISS cell surface
GO:0010976 IEA positive regulation of neuron projection development
GO:0016021 IEA integral component of membrane
GO:0019901 ISS protein kinase binding
GO:0030295 IDA protein kinase activator activity
GO:0031410 IEA cytoplasmic vesicle
GO:0042593 IEA glucose homeostasis
GO:0043123 ISS positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045121 IEA membrane raft
GO:0045666 ISS positive regulation of neuron differentiation
GO:0045860 IEA positive regulation of protein kinase activity
GO:0050729 ISS positive regulation of inflammatory response
GO:0060907 ISS positive regulation of macrophage cytokine production
GO:0061098 ISS positive regulation of protein tyrosine kinase activity
GO:0070062 IDA extracellular vesicular exosome
GO:0090263 ISS positive regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075141 gprc5bb G protein-coupled receptor, family C, group 5, member Bb protein_coding Danio_rerio
ENSDARG00000077080 gprc5ba G protein-coupled receptor, family C, group 5, member Ba protein_coding Danio_rerio
ENSMUSG00000008734 Gprc5b G protein-coupled receptor, family C, group 5, member B protein_coding Mus_musculus

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