C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ribonucleotide reductase M1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167325 RRM1 9606 + 11:4094707-4138876 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000300738 RRM1-001 4094809-4138876 protein_coding
  ENST00000526304 RRM1-012 4119062-4123270 processed_transcript
  ENST00000526350 RRM1-010 4094852-4107570 retained_intron
  ENST00000526865 RRM1-009 4094805-4106147 processed_transcript
  ENST00000528442 RRM1-014 4111975-4123384 nonsense_mediated_decay
  ENST00000528470 RRM1-013 4119069-4123271 processed_transcript
  ENST00000529109 RRM1-015 4122109-4126817 retained_intron
  ENST00000530368 RRM1-011 4101928-4106223 retained_intron
  ENST00000531591 RRM1-016 4121675-4126949 retained_intron
  ENST00000532170 RRM1-017 4094799-4138870 nonsense_mediated_decay
  ENST00000532710 RRM1-008 4094707-4107480 processed_transcript
  ENST00000533349 RRM1-003 4094843-4138875 nonsense_mediated_decay
  ENST00000533495 RRM1-006 4116243-4138875 nonsense_mediated_decay
  ENST00000534285 RRM1-005 4116078-4138446 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000300738ENST00000526304ENST00000531591ENST00000533349ENST00000533495ENST00000534285
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000300738 7.826±0.00 4.105±0.00 2.043±0.00 5.284±0.26 8.881±3.66 4.815±0.25 3.750±1.05 3.631±0.71 4.102±1.91 3.962±0.06 7.489±6.03 9.306±2.72 13.526±3.58 6.171±1.21
ENST00000526304 N/A N/A N/A N/A N/A N/A N/A 7.979±0.00 N/A N/A 6.123±0.00 N/A N/A 12.778±0.00
ENST00000531591 N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.590±0.00 N/A N/A N/A N/A
ENST00000533349 N/A 1.616±0.00 N/A N/A N/A 3.213±0.00 N/A N/A N/A 1.077±0.00 N/A 4.911±0.00 6.615±0.00 4.061±1.31
ENST00000533495 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.341±0.00
ENST00000534285 N/A N/A 1.211±0.00 3.093±0.00 N/A N/A 1.643±0.10 1.416±0.00 5.346±0.00 1.398±0.00 2.287±0.00 5.137±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005LF CIL_0005LF_0001 CGP 11:3854527-4138876

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000278 IEA mitotic cell cycle
GO:0004748 ISS:IEA ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005635 IEA nuclear envelope
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006206 IEA pyrimidine nucleobase metabolic process
GO:0006260 IEA DNA replication
GO:0008584 IEA male gonad development
GO:0009263 ISS deoxyribonucleotide biosynthetic process
GO:0010212 IEA response to ionizing radiation
GO:0015949 TAS nucleobase-containing small molecule interconversion
GO:0017076 IEA purine nucleotide binding
GO:0021846 IEA cell proliferation in forebrain
GO:0042995 IEA cell projection
GO:0043025 IEA neuronal cell body
GO:0044281 TAS small molecule metabolic process
GO:0051259 IEA protein oligomerization
GO:0051290 IEA protein heterotetramerization
GO:0055086 TAS nucleobase-containing small molecule metabolic process
GO:0055114 IEA oxidation-reduction process
GO:0060041 IEA retina development in camera-type eye
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014017 rrm1 ribonucleotide reductase M1 polypeptide protein_coding Danio_rerio
ENSMUSG00000030978 Rrm1 ribonucleotide reductase M1 protein_coding Mus_musculus

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