C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mevalonate (diphospho) decarboxylase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167508 MVD 9606 - 16:88651935-88663161 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000301012 MVD-001 88651935-88663110 protein_coding
  ENST00000561895 MVD-004 88652510-88654985 retained_intron
  ENST00000562651 MVD-011 88657436-88660872 retained_intron
  ENST00000562741 MVD-014 88662102-88663161 processed_transcript
  ENST00000562981 MVD-003 88652354-88653584 retained_intron
  ENST00000563170 MVD-012 88656121-88663065 retained_intron
  ENST00000563463 MVD-016 88658973-88663079 processed_transcript
  ENST00000563785 MVD-006 88655834-88663094 retained_intron
  ENST00000565149 MVD-002 88651935-88657266 retained_intron
  ENST00000565610 MVD-017 88657944-88663148 nonsense_mediated_decay
  ENST00000565720 MVD-005 88656261-88657507 processed_transcript
  ENST00000565842 MVD-015 88662115-88663046 processed_transcript
  ENST00000566636 MVD-010 88656170-88658783 retained_intron
  ENST00000567064 MVD-013 88655657-88663091 nonsense_mediated_decay
  ENST00000568133 MVD-009 88655663-88663082 nonsense_mediated_decay
  ENST00000568709 MVD-008 88656105-88663029 processed_transcript
  ENST00000569177 MVD-007 88655385-88663137 protein_coding
  ENST00000620002 MVD-201 88651940-88663110 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000301012ENST00000562741ENST00000563463ENST00000563785ENST00000565149ENST00000565610ENST00000567064ENST00000569177ENST00000620002
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000301012 N/A N/A N/A 3.620±1.06 N/A 0.392±0.00 2.702±0.00 0.073±0.00 N/A 6.270±0.00 0.917±0.00 N/A N/A N/A
ENST00000562741 N/A N/A 2.333±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000563463 N/A N/A N/A N/A N/A 0.962±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000563785 N/A N/A N/A N/A N/A 0.311±0.00 N/A N/A 0.516±0.00 N/A N/A N/A N/A N/A
ENST00000565149 N/A 2.445±0.00 N/A 1.814±0.00 N/A N/A N/A N/A N/A 3.655±0.00 N/A 0.416±0.00 N/A N/A
ENST00000565610 N/A N/A N/A 2.974±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000567064 N/A N/A N/A 2.410±0.00 1.043±0.00 N/A N/A 0.425±0.00 0.777±0.00 1.863±0.00 0.126±0.00 2.034±0.00 N/A 16.209±0.00
ENST00000569177 N/A N/A N/A N/A N/A N/A N/A 0.399±0.00 N/A N/A N/A 4.036±3.52 4.445±0.00 14.561±0.00
ENST00000620002 13.712±0.00 14.369±0.00 0.269±0.00 4.721±0.00 17.554±0.00 8.554±8.16 1.566±1.21 7.878±7.80 22.892±0.00 17.882±0.00 4.272±0.00 16.336±13.99 10.092±3.60 32.003±11.87

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00032Y CIL_00032Y_0001 CGP 16:88643283-88663161
CIL_00032X CIL_00032X_0001 CGP 16:88651935-88686493

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004163 IDA:IEA diphosphomevalonate decarboxylase activity
GO:0005524 IEA ATP binding
GO:0005829 IDA:IEA cytosol
GO:0006488 TAS dolichol-linked oligosaccharide biosynthetic process
GO:0006489 TAS dolichyl diphosphate biosynthetic process
GO:0006695 IEA cholesterol biosynthetic process
GO:0008284 IMP positive regulation of cell proliferation
GO:0008299 IDA:IEA isoprenoid biosynthetic process
GO:0016301 IEA kinase activity
GO:0016310 IEA phosphorylation
GO:0016831 IEA carboxy-lyase activity
GO:0018279 TAS protein N-linked glycosylation via asparagine
GO:0019287 IEA isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0030544 IPI Hsp70 protein binding
GO:0042803 IDA protein homodimerization activity
GO:0043687 TAS post-translational protein modification
GO:0044267 TAS cellular protein metabolic process
GO:0044281 TAS small molecule metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074035 mvda mevalonate (diphospho) decarboxylase a protein_coding Danio_rerio
ENSMUSG00000006517 Mvd mevalonate (diphospho) decarboxylase protein_coding Mus_musculus

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