C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sclerostin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167941 SOST 9606 - 17:43753731-43758788 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000301691 SOST-001 43753731-43758788 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainHeartKidneyLiverLungOvaryPlacentaTestisENST00000301691
Transcript ID Bladder Brain Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000301691 0.928±0.00 0.128±0.08 0.091±0.05 1.048±0.00 0.096±0.00 0.172±0.06 0.026±0.01 0.025±0.00 0.036±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000996 CIL_000996_0001 VISTA 17:43262867-43863532
CIL_00090X CIL_00090X_0001 VISTA 17:43291368-43892559
CIL_000997 CIL_000997_0001 VISTA 17:43327654-43928719
CIL_00059O CIL_00059O_0001 CGP 17:43640388-43758788
CIL_0001CB CIL_0001CB_0001 CGP 17:43753731-43778988

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001503 IEA ossification
GO:0005515 IPI protein binding
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IEA extracellular space
GO:0005794 IEA Golgi apparatus
GO:0008134 IDA transcription factor binding
GO:0008201 IEA heparin binding
GO:0009612 IEP response to mechanical stimulus
GO:0016055 IEA Wnt signaling pathway
GO:0030178 IEA negative regulation of Wnt signaling pathway
GO:0030279 NAS negative regulation of ossification
GO:0030514 IDA negative regulation of BMP signaling pathway
GO:0031012 IDA extracellular matrix
GO:0031333 IDA negative regulation of protein complex assembly
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0071374 IDA cellular response to parathyroid hormone stimulus
GO:0090090 IDA negative regulation of canonical Wnt signaling pathway
GO:2000054 IDA negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061259 sost sclerostin protein_coding Danio_rerio
ENSMUSG00000001494 Sost sclerostin protein_coding Mus_musculus

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