C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein tyrosine kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169398 PTK2 9606 - 8:140657900-141002216 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000340930 PTK2-011 140658405-141001158 protein_coding
  ENST00000395218 PTK2-201 140658382-141001313 protein_coding
  ENST00000430260 PTK2-006 140659073-140718734 protein_coding
  ENST00000510126 PTK2-022 140744701-140747272 retained_intron
  ENST00000517453 PTK2-043 140879480-141002110 protein_coding
  ENST00000517712 PTK2-004 140658405-140670264 protein_coding
  ENST00000517887 PTK2-008 140658402-140921219 protein_coding
  ENST00000518173 PTK2-056 140700770-140706168 retained_intron
  ENST00000518509 PTK2-048 140717689-140744803 processed_transcript
  ENST00000519024 PTK2-053 140744685-140764421 protein_coding
  ENST00000519361 PTK2-025 140746834-140765236 processed_transcript
  ENST00000519419 PTK2-007 140658630-140954835 protein_coding
  ENST00000519465 PTK2-005 140658402-140764523 protein_coding
  ENST00000519635 PTK2-029 140925689-141002216 processed_transcript
  ENST00000519654 PTK2-010 140658389-140890768 protein_coding
  ENST00000519881 PTK2-037 140879162-141001284 protein_coding
  ENST00000519899 PTK2-023 140746450-140764401 retained_intron
  ENST00000519993 PTK2-013 140658405-141001379 nonsense_mediated_decay
  ENST00000520045 PTK2-044 140879482-141001285 protein_coding
  ENST00000520151 PTK2-054 140743237-140764413 protein_coding
  ENST00000520460 PTK2-016 140668289-140675779 processed_transcript
  ENST00000520475 PTK2-033 140846659-140934560 protein_coding
  ENST00000520828 PTK2-041 140846649-141001164 protein_coding
  ENST00000520843 PTK2-024 140750203-140764260 processed_transcript
  ENST00000520892 PTK2-038 140879441-141000937 protein_coding
  ENST00000520917 PTK2-021 140735045-140744702 retained_intron
  ENST00000521029 PTK2-051 140706157-140764353 nonsense_mediated_decay
  ENST00000521059 PTK2-057 140658402-141001196 protein_coding
  ENST00000521172 PTK2-028 140752232-140771444 processed_transcript
  ENST00000521250 PTK2-049 140700943-140800549 nonsense_mediated_decay
  ENST00000521332 PTK2-039 140890543-141001266 protein_coding
  ENST00000521395 PTK2-034 140879512-140934590 protein_coding
  ENST00000521562 PTK2-019 140700924-140718355 protein_coding
  ENST00000521791 PTK2-031 140830476-141000926 nonsense_mediated_decay
  ENST00000521907 PTK2-035 140879476-140983994 protein_coding
  ENST00000521981 PTK2-052 140702698-140800543 nonsense_mediated_decay
  ENST00000521985 PTK2-018 140686870-140702715 processed_transcript
  ENST00000521986 PTK2-009 140659335-140800543 protein_coding
  ENST00000522424 PTK2-047 140700921-140721788 protein_coding
  ENST00000522684 PTK2-001 140657900-141001233 protein_coding
  ENST00000522950 PTK2-014 140659620-140663088 protein_coding
  ENST00000523067 PTK2-046 140846607-141001167 nonsense_mediated_decay
  ENST00000523388 PTK2-020 140702665-140718048 protein_coding
  ENST00000523435 PTK2-015 140659487-140663084 protein_coding
  ENST00000523474 PTK2-027 140744747-140770966 processed_transcript
  ENST00000523539 PTK2-002 140658405-140800546 protein_coding
  ENST00000523670 PTK2-050 140743290-140764419 nonsense_mediated_decay
  ENST00000523675 PTK2-036 140890316-140921009 retained_intron
  ENST00000523679 PTK2-040 140920870-141001177 protein_coding
  ENST00000523746 PTK2-026 140744697-140799297 processed_transcript
  ENST00000523797 PTK2-030 140925588-141001122 processed_transcript
  ENST00000523803 PTK2-032 140879471-140984039 protein_coding
  ENST00000523805 PTK2-017 140668279-140686778 processed_transcript
  ENST00000524040 PTK2-045 140890584-141001266 protein_coding
  ENST00000524202 PTK2-003 140659071-140846290 nonsense_mediated_decay
  ENST00000524257 PTK2-042 140920890-141001164 protein_coding
  ENST00000524357 PTK2-055 140818984-141001260 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000340930ENST00000395218ENST00000430260ENST00000517712ENST00000517887ENST00000519654ENST00000519993ENST00000520475ENST00000521059ENST00000521986ENST00000523539
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000340930 N/A N/A N/A N/A N/A N/A 2.283±0.00 3.283±0.00 N/A N/A N/A 2.596±0.00 N/A 4.365±0.00
ENST00000395218 N/A 3.138±0.00 N/A N/A N/A 6.817±0.00 3.019±0.00 N/A N/A 4.078±0.00 2.042±0.00 4.301±0.00 5.265±1.33 N/A
ENST00000430260 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.421±0.00 N/A 12.703±0.00 N/A
ENST00000517712 N/A N/A N/A 9.287±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000517887 N/A N/A 2.662±0.00 9.071±0.00 4.162±0.00 N/A N/A 1.797±0.00 4.165±0.00 6.839±0.00 N/A N/A N/A N/A
ENST00000519654 7.324±0.00 4.911±0.00 N/A 8.067±0.00 6.326±2.63 N/A N/A 6.564±0.00 1.755±0.00 N/A N/A 4.008±0.00 6.625±0.00 8.614±0.00
ENST00000519993 3.432±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.051±0.00 N/A N/A 4.298±0.00
ENST00000520475 N/A N/A N/A N/A N/A 33.208±0.00 N/A N/A 57.609±0.00 N/A N/A N/A N/A N/A
ENST00000521059 3.634±0.00 N/A N/A N/A N/A 6.687±0.00 3.089±0.00 N/A N/A 3.706±0.00 1.423±0.85 10.929±1.64 9.366±4.66 8.686±0.00
ENST00000521986 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.727±1.85 7.497±0.00 N/A N/A
ENST00000523539 N/A 8.845±0.00 N/A 19.491±0.00 N/A 6.563±0.00 3.320±0.00 N/A 2.912±0.00 4.993±0.00 N/A 4.186±0.00 N/A 6.164±0.27

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002XD CIL_0002XD_0001 CGP 8:140531165-141002216
CIL_0006FQ CIL_0006FQ_0002 CGP 8:140657900-141195808

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000226 IEA microtubule cytoskeleton organization
GO:0001525 TAS angiogenesis
GO:0001568 IEA blood vessel development
GO:0001570 IEA vasculogenesis
GO:0001725 IDA stress fiber
GO:0001764 IEA neuron migration
GO:0001890 TAS placenta development
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0003007 TAS heart morphogenesis
GO:0003779 IDA actin binding
GO:0004672 TAS:IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0004871 IEA signal transducer activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005829 IDA cytosol
GO:0005856 IEA:TAS cytoskeleton
GO:0005925 IDA:IEA focal adhesion
GO:0006468 IEA protein phosphorylation
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0007165 IEA signal transduction
GO:0007172 IEA signal complex assembly
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007229 IMP integrin-mediated signaling pathway
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008284 ISS positive regulation of cell proliferation
GO:0008360 IMP regulation of cell shape
GO:0008432 IDA JUN kinase binding
GO:0009790 TAS embryo development
GO:0010594 TAS regulation of endothelial cell migration
GO:0014068 IMP positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016324 IEA apical plasma membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA:IDA peptidyl-tyrosine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0021955 IEA central nervous system neuron axonogenesis
GO:0022408 IDA negative regulation of cell-cell adhesion
GO:0030010 TAS establishment of cell polarity
GO:0030027 IEA lamellipodium
GO:0030168 TAS platelet activation
GO:0030198 IEA extracellular matrix organization
GO:0030335 IDA positive regulation of cell migration
GO:0032319 TAS regulation of Rho GTPase activity
GO:0033628 IDA regulation of cell adhesion mediated by integrin
GO:0038007 TAS netrin-activated signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0040023 IEA establishment of nucleus localization
GO:0042127 IMP regulation of cell proliferation
GO:0042169 IPI SH2 domain binding
GO:0043066 IMP negative regulation of apoptotic process
GO:0043542 IEA endothelial cell migration
GO:0043552 TAS positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 TAS innate immune response
GO:0045667 IMP regulation of osteoblast differentiation
GO:0045860 IMP positive regulation of protein kinase activity
GO:0046621 IEA negative regulation of organ growth
GO:0046777 IDA protein autophosphorylation
GO:0048013 IDA ephrin receptor signaling pathway
GO:0048870 TAS cell motility
GO:0050771 IEA negative regulation of axonogenesis
GO:0051493 TAS regulation of cytoskeleton organization
GO:0051893 TAS regulation of focal adhesion assembly
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0051964 IEA negative regulation of synapse assembly
GO:0060396 IDA growth hormone receptor signaling pathway
GO:2000060 ISS positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811 IMP negative regulation of anoikis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004672 ptk2.1 protein tyrosine kinase 2a protein_coding Danio_rerio
ENSDARG00000040197 ptk2.2 protein tyrosine kinase 2b protein_coding Danio_rerio
ENSMUSG00000022607 Ptk2 PTK2 protein tyrosine kinase 2 protein_coding Mus_musculus

Loading