C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: BUB1 mitotic checkpoint serine/threonine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169679 BUB1 9606 - 2:110637698-110678114 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302759 BUB1-001 110637834-110678114 protein_coding
  ENST00000409311 BUB1-002 110637832-110678063 protein_coding
  ENST00000420328 BUB1-005 110670562-110678041 protein_coding
  ENST00000436916 BUB1-006 110674116-110675297 protein_coding
  ENST00000447014 BUB1-007 110670525-110678033 protein_coding
  ENST00000465029 BUB1-003 110660868-110678063 retained_intron
  ENST00000466333 BUB1-004 110642114-110678028 retained_intron
  ENST00000468927 BUB1-008 110665962-110669475 retained_intron
  ENST00000477481 BUB1-009 110661356-110667565 retained_intron
  ENST00000478175 BUB1-011 110641326-110642790 processed_transcript
  ENST00000490632 BUB1-010 110648817-110650739 retained_intron
  ENST00000535254 BUB1-201 110637698-110678107 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000302759ENST00000409311ENST00000447014ENST00000465029ENST00000466333ENST00000468927ENST00000478175ENST00000535254
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000302759 0.156±0.00 0.210±0.00 N/A N/A 0.345±0.11 0.746±0.68 N/A N/A 0.039±0.00 0.354±0.00 5.117±4.10 1.018±0.26 11.844±3.56
ENST00000409311 N/A N/A N/A 0.093±0.00 N/A N/A 0.129±0.00 0.040±0.03 N/A N/A N/A N/A 1.614±0.00
ENST00000447014 N/A N/A N/A 0.109±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000465029 N/A N/A 0.073±0.00 0.017±0.00 N/A 1.221±0.00 N/A N/A 0.085±0.00 N/A N/A N/A N/A
ENST00000466333 N/A N/A N/A N/A N/A N/A N/A 0.030±0.00 0.032±0.00 N/A N/A N/A N/A
ENST00000468927 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.837±0.00 N/A N/A N/A
ENST00000478175 N/A N/A N/A N/A N/A N/A 0.205±0.00 N/A N/A N/A N/A N/A N/A
ENST00000535254 N/A 0.162±0.00 N/A N/A N/A N/A 0.016±0.00 N/A N/A N/A 0.811±0.48 0.704±0.00 2.598±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00047T CIL_00047T_0001 CGP 2:110637698-111118222

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000278 TAS mitotic cell cycle
GO:0000775 IEA chromosome, centromeric region
GO:0000776 IDA kinetochore
GO:0000777 IDA condensed chromosome kinetochore
GO:0000780 IEA condensed nuclear chromosome, centromeric region
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007059 IEA chromosome segregation
GO:0007063 IDA regulation of sister chromatid cohesion
GO:0007067 IEA mitotic nuclear division
GO:0007093 TAS mitotic cell cycle checkpoint
GO:0007094 TAS mitotic spindle assembly checkpoint
GO:0008283 IEA cell proliferation
GO:0016020 IDA membrane
GO:0016032 IEA viral process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0051983 IMP regulation of chromosome segregation
GO:0071173 IDA spindle assembly checkpoint
GO:0071174 IEA mitotic spindle checkpoint
GO:2001244 IEA positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000077029 bub1 BUB1 mitotic checkpoint serine/threonine kinase protein_coding Danio_rerio
ENSMUSG00000027379 Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) protein_coding Mus_musculus

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