C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SMAD family member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000170365 SMAD1 9606 + 4:145481194-145558079 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302085 SMAD1-001 145481792-145558079 protein_coding
  ENST00000394092 SMAD1-015 145482805-145557954 protein_coding
  ENST00000502342 SMAD1-011 145525720-145539969 processed_transcript
  ENST00000503324 SMAD1-006 145482486-145514788 protein_coding
  ENST00000506626 SMAD1-017 145484513-145514703 processed_transcript
  ENST00000507367 SMAD1-012 145482792-145514643 protein_coding
  ENST00000507594 SMAD1-004 145481306-145514900 protein_coding
  ENST00000510948 SMAD1-018 145546077-145554035 processed_transcript
  ENST00000511125 SMAD1-014 145544178-145558079 retained_intron
  ENST00000511255 SMAD1-019 145546520-145553917 retained_intron
  ENST00000512019 SMAD1-007 145481871-145515013 protein_coding
  ENST00000514168 SMAD1-013 145482813-145514493 processed_transcript
  ENST00000514778 SMAD1-003 145481194-145514932 protein_coding
  ENST00000514831 SMAD1-005 145481698-145514951 protein_coding
  ENST00000515385 SMAD1-002 145482811-145558079 protein_coding
  ENST00000515527 SMAD1-016 145482498-145514746 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderColonHeartKidneyLiverLungMuscleOvaryPlacentaENST00000302085ENST00000394092ENST00000511125
Transcript ID Bladder Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENST00000302085 2.135±0.00 1.894±0.00 N/A 1.139±0.00 1.839±0.00 N/A 0.492±0.00 N/A 1.525±0.00
ENST00000394092 N/A N/A 0.462±0.00 0.839±0.00 0.869±0.00 2.008±0.00 N/A N/A N/A
ENST00000511125 N/A N/A 0.275±0.00 N/A 0.453±0.00 N/A N/A 0.630±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001657 IEA ureteric bud development
GO:0001710 IEA mesodermal cell fate commitment
GO:0001822 IEA kidney development
GO:0002051 IEA osteoblast fate commitment
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0005057 NAS receptor signaling protein activity
GO:0005515 IPI:IEA protein binding
GO:0005622 NAS:IEA intracellular
GO:0005634 IDA nucleus
GO:0005637 IDA nuclear inner membrane
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006468 IEA protein phosphorylation
GO:0006954 IEA inflammatory response
GO:0007165 NAS signal transduction
GO:0007179 IEA:NAS transforming growth factor beta receptor signaling pathway
GO:0007183 IDA SMAD protein complex assembly
GO:0007276 IEA gamete generation
GO:0008285 IEA negative regulation of cell proliferation
GO:0009880 ISS embryonic pattern specification
GO:0010243 IEA response to organonitrogen compound
GO:0010628 IDA positive regulation of gene expression
GO:0010656 IEA negative regulation of muscle cell apoptotic process
GO:0016021 NAS integral component of membrane
GO:0019901 IPI protein kinase binding
GO:0030509 ISS BMP signaling pathway
GO:0030618 TAS transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0030901 IEA midbrain development
GO:0030902 IEA hindbrain development
GO:0031053 TAS primary miRNA processing
GO:0042060 IEA wound healing
GO:0042493 IEA response to drug
GO:0042592 IEA homeostatic process
GO:0042802 IPI identical protein binding
GO:0043234 IDA protein complex
GO:0045597 IEA positive regulation of cell differentiation
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045944 IC positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0050775 IEA positive regulation of dendrite morphogenesis
GO:0051216 IEA cartilage development
GO:0060038 IEA cardiac muscle cell proliferation
GO:0060348 IEA bone development
GO:0061036 IEA positive regulation of cartilage development
GO:0070410 IPI co-SMAD binding
GO:0070411 IPI I-SMAD binding
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071773 ISS cellular response to BMP stimulus
GO:1901522 ISS positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000031681 Smad1 SMAD family member 1 protein_coding Mus_musculus

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